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Flashcards in Antihelminths Deck (35):
1

overall MOA of benzimidazoles

- bind to free beta-tubulin and inhibiting the polymerization of tubulin and microtubule-dependent glucose uptake

2

indications of albendazole

- neurocysticercosis caused by T. solium
- hydatid disease

3

AE of albendazole

- dizziness
- vertigo
- increased ICP
- meningeal signs, seizures

4

CI of albendazole

- pregnancy

5

indications of mebendazole

- enterobius vermicularis
- trichuris trichiura
- ascaris lumbricoides
- hook worms

6

AE of mebendazole

- angioedema, SJ syndrome when combined with metronidazole

7

CI of mebendazole

- pregnancy: embyrotoxic and teratogenic

8

indications of thiabendazole

- cutaneous larva migrans
- visceral larva migrans (toxocara canis)
- trichinosis

- drinking fruit juice aids in expulsion of worms

9

AE of thiabendazole

- hepatoxicity and nephrotoxicity
- angioedema
- pruritus
- rash
- SJ syndrome

10

MOA of ivermectin

- binds to glutamate-gated chloride channels in the nerve and muscle cell
- does not cross the BBB

11

indications of ivermectin

- onchocerca volvulus
- strongyloidiasis
- onchocerciasis (river blindness)

12

AE of ivermectin

- dizziness, encephalopathy, headache, hyperthermia, insomnia, seizure, somnolence, vertigo
- ALT/AST increased, bilirubin increased
- Mazzotti reaction - arthralgia, pruritus, rash, synovitus

13

CI of ivermectin

- meningitis patients
- pregnancy

14

MOA of diethylcarbamazine

- inhibit arachidonic acid metabolism in filarial mitochondria which enhances destruction by host

15

indications of diethylcarbamazine

- lymphatic filariasis (Wucheria bancrofti)
- treatment most effect if given with albendazole

16

AE of diethylcarbamazine

- Mazzotti reaction - aggravation of ocular lesions and hypotension

17

MOA of pyrantel pamoate

- neuromuscular blocker

18

indications of pyrantel pamoate

- second line for pinworm, trichuriasis, and roundworm

19

AE of pyrantel pamoate

- anorexia, N/V/D, transient increase in hepatic enzymes

- category C for pregnancy

20

indications of praziquantel

- all stages of schistosomiasis, clonorchiasis, opistorchiasis

21

AE of praziquantel

- CSF reaction syndrome in patients being treated for neurocysticercosis - headaches, seizures, meningismus

22

MOA of niclosamide

- inhibits mitochondrial anaerobic phosphorylation of ADP in tapeworms

23

indications of niclosamide

- tapeworms
- diphyloobothrium latum

24

DOC for neurocysticercosis

- albendazole or praziquantel

25

DOC for hookworms (A. duodenale or N. americanus)

- mebendazole

26

DOC for ascaris lumbricoides

- mebendazole
- second line - pyrantel pamoate

27

DOC for enterobius vermicularis

- mebendazole
- second line - albendazole, thiabendazole, pyrantel pamoate

28

DOC or trichuris thrichuria

- mebendazole

29

DOC for visceral larva migrans (toxocara spp)

- thiabendazole
- second line - diethylcarbamazine

30

DOC for cutaneous larva migrans (ancylostoma braziliense)

- thiabendazole

31

DOC for strongyloides stercoralis

- ivermectin

32

DOC for river blindness (onchocerca volvulus)

- ivermectin

33

DOC for wuchereria bancrofti

- diethylcarbamazine and albendazole

34

DOC for schistosomiasis

- praziquantel

35

drugs that can cause Mazzotti reaction

- ivermectin
- diethylcarbamazine (most common)