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Flashcards in Antiprotozoans Deck (28):
1

indications of metronidazole

- trichomoniasis
- amebiasis
- giardiasis

2

AE of metronidazole

- disulfiram-like reactions, nausea, peripheral neuropathy

3

CI of metronidazole

- pregnancy

4

indications of tinidazole

- trichomoniasis
- amebiasis
- giardiasis

5

AE of tinidazole

- bitter taste
- acute hypersensitivity reaction (severe), erythema multiforme, SJ syndrome

6

indications of nitazoxanide

- diarrhea treatment of crypto in immune competent patients
- diarrhea due to giardia

7

indications of atovaquone

- pneuomocystic jiroveci in patients who are intolerant to TMP-SMX

- primary prophylaxis for PCP in HIV pt at high risk of toxo encephalitis

8

indications of pentamidine

- treatment and prevention of pneumonia caused by pneumocystic jiroveci

9

AE of pentamidine

- cardiac arrythmias
- permanent insulin requiring DM
- pneumonia may still occur despite treatment

10

indications of pyrimethamine

- prophylaxis of malaria
- synergistic combo with sulfonamide in treatment of toxo

11

AE of pyrimethamine

- must monitor CBC and platelet counts
- discontinue at first sign of rash, report bleeding or bruising
- take with food to minimize vomiting

12

indications of sulfadiazine

- toxo

13

AE of sulfadiazine

- SJ syndrome, photosensitivity
- supplemental folic acid must be given to avoid folic acid deficiency

14

DOC for trichomonas vaginalis

- metronidazole and tinidazole

15

DOC for giardia

- metronidazole and tinidazole

16

DOC for entamoeba histolytica

- asymptomatic- paraomomycin
- symptomatic - metronidazole or tinidazole immediately followed by paramomycin

17

DOC for babesiosis

- clindamycin with quinine OR
- atovaquone with azithromycin

18

DOC for chagas

- nifurtimox

19

DOC for trypanosoma brucei

- hemolymphatic state of TB. gambiense (west africa) -pentamidine isethionate
- hemolymphatic state of Tb. rhodesiense (east africa) - sumarin
- late disease with CNS involvement- melarsoprol

20

DOC for cryptosporidiosis

- nitazoxanide for immunoCOMPETENT pts.
- HIV pts use HAART

21

DOC for cyclosporiasis

- TMP-SMX

22

DOC for microsporidiosis

- albendazole

23

DOC for pneumocystis jiroveci

- TMP-SMX

24

DOC for toxoplasmosis

- pyrimethamine with sulfadiazine OR
- pyrimethamine with clindamycin

25

DOC for uncomplicated P. falciparum or species not identified

- chloroquine phosphate or hydroxychloroquine

26

DOC for chloroquine resistant malaria or unknown restistance

- quinine + (doxy, tetracycline, OR clindamycin) OR
- atovaquone-progunail
OR
- mefloquine

27

DOC for P. vivax or P ovale

- chloroquine with primaquine
OR
- mefloquine with primaquine

28

DOC for severe malaria in all regions

- quinidine with doxy, tetracycline, or clindamycin