Antihyperglycemic drugs (Biguanides ans thiazolidinediones) Flashcards Preview

35 Diabetes mellitus > Antihyperglycemic drugs (Biguanides ans thiazolidinediones) > Flashcards

Flashcards in Antihyperglycemic drugs (Biguanides ans thiazolidinediones) Deck (12)
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1

Antihyperglycemic drugs (5 groups)

Biguanides
Thiazolidinediones
α-glucosinidase inhibitors
Incretin mimetics
Amylin analogue

2

Biguanides (1 drugs)

Metformin

3

Metformin - MOA

Decreases hepatic glucose output and glucose absorption from the gut. Increases glucose uptake and usage in skeletal muscle and adipose tissue. Does NOT stimulate insulin secretion

4

Metformin - contraindications

Renal/hepatic disease
Alcoholism
Predisposition for lactic acidosis

5

What is the most serious adverse effect of metformin?

Lactic acidosis

6

Metformin - adverse effects

Decreased weight
Diarrhea
Lactic acidosis

7

Metformin - interactions

Cimetidine - inhibits metabolism of metformin

8

Thiazolidinediones (2 drugs)

Pioglitazone
Rosiglitazone

9

Thiazolidinediones - MOA

Agonists of PPAR- γ. Increases transcription GLUT-4 transporters. Results in ⇑insulin sensitivity and ⇓insulin resistance. Suppress hepatic glucose output

10

Thiazolidinediones - Contraindications

Risk of heart failure

11

Pioglitazone - indications

Poorly controlled DM2 unable or unwilling to use insulin.

12

Which DM drugs increases risk of cardiovascular events?

Pioglitazone
Rosiglitazone
(Thiazolidinediones)