Antihyperglycemic drugs (α-glucosinidase inh, incretin mimetics, amylin analogue) Flashcards Preview

35 Diabetes mellitus > Antihyperglycemic drugs (α-glucosinidase inh, incretin mimetics, amylin analogue) > Flashcards

Flashcards in Antihyperglycemic drugs (α-glucosinidase inh, incretin mimetics, amylin analogue) Deck (15)
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1

α-glucosinidase inhibitors (2 drugs)

Acarbose
Miglitol

2

α-glucosinidase inhibitors - MOA

Competitive inhibition of α-Glucosinidase, delaying starch and disaccharide digestion. Also ⇓ glucose absorption. Postprandial hypoglycemia

3

How are α-glucosinidase inhibitors administered?

Orally, at first bite of food

4

Which drug increases the bioavailability of metformin?

Acarbose

5

Miglitol - adverse effects

Flatulence

6

Incretin mimetics (5 drugs, 2 subgroups)

Exenatide: GLP-1 mimetic
Liraglutide: GLP-1 mimetic
Sitagliptin: DPP-4 inhibitor
Linagliptin: DPP-4 inhibitor
Saxagliptin: DPP-4 inhibitor

7

GLP-1 mimetics - MOA

Stimulation of glucose-dependent insulin secretion, ⇑ uptake of glucose by muscle and fat tissue, ⇓glucagon secretion, slowed gastric emptying, ⇑satiety, and ⇓ food intake.

8

Which incretin mimetics are associated with pancreatitis?

Exenatide, liraglutide (GLP-1 mimetics)

9

Which incretin mimetic is associated with thyroid C-cell turmor

Liraglutide

10

DPP-4 inhibitors - MOA

Increases GLP-1 levels: Stimulation of glucose-dependent insulin secretion, ⇑ uptake of glucose by muscle and fat tissue, ⇓glucagon secretion, slowed gastric emptying, ⇑satiety, and ⇓ food intake.

11

DPP-4 inhibitors - indications

Improve control in DM2

12

Sitagliptin, linagliptin and saxagliptin are especially useful for

Old and frail people

13

Amylin analogue (1 drug)

Pramlintide acetate

14

Amylin analogue - MOA

⇓Rate of rise of blood glucose by slowing gastric emptying, suppressing glucagon secretion and glucose output by the liver, ⇓appetite

15

Pramlintide acetate - indications

DM1 and DM2 on insulin treatment. Weight loss