Hypoglycemic drugs + dopamine agonist Flashcards Preview

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Flashcards in Hypoglycemic drugs + dopamine agonist Deck (16)
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1

Hypoglycemic drugs (2 groups)

Sulfonylurea drugs
Meglitinide drugs

2

2nd generation sulfonylureas (3 drugs)

Glimepiride
Glipizide
Glyburide

3

Sulfonylurea drugs - MOA

1) Inh ATP-sensitive potassium channels, activation of pulsatile insulin secretion. No effect on basal insulin secretion.
2) Decreasing glucagon secretion by ⇑ insulin and pancreatic somatostatin secretion.
3) Increase insulin sensitivity in DM2

4

Can sulfonylurea drugs be combined with metformin?

Yeah

5

Sulfonylurea drugs - adverse effects

Weight gain
Hypoglycemia
Cholestasis
Hematologic reactions

6

The effectiveness of sulfonylurea drugs is decreased by (5 drugs)

Thiazide diuretics
Corticosteroids
Estrogens
Thyroid hormones
Phenytoin

7

The hypoglycemic effect of sulfonylurea drugs is increased by (5 drugs)

ACE-inhibitors
Sulfonamides
Salicylates + other NSAIDs
Gemfibrozil
Alcohol

8

What should be avoided in sulfonylurea treatment?

High alcohol consumption - disulfiram-like reaction

9

Meglitinide drugs (2 drugs)

Repaglinide
Nateglinide

10

Meglitinide drugs- MOA

Inh ATP-sensitive potassium channels, preventing K+-efflux and causing Ca2+-influx and activation of pulsatile insulin secretion. No effect on basal insulin secretion.

11

Meglitinides - indications

Postprandial glycemia
DM2 (1st line)

12

Can meglitinides be used with metformin?

Yaas

13

Meglitinides should not be used with

Other oral antidiabetic drugs or insulin. (metformin is ok)

14

First-line drugs for DM2 (4 drugs/groups)

Metformin
Incretin mimetics
Sulfonylureas
Meglitinides

15

Dopamine agonist that is studied for its effect in DM

Bromocriptine

16

Bromocriptine - MOA for DM

Resets disturbed circadian rhythm and reduces hepatic glucose output. Causes decreased insulin resistance