Antihypertensives Flashcards Preview

Clinical Pharm > Antihypertensives > Flashcards

Flashcards in Antihypertensives Deck (60):
1

metoprolol (lopressor) MOA

B1 blocker
B2 with increased dose

2

Metoprolol (lopressor) bolus dose

2.5-5 mg q 2 minutes

3

Metoprolol (lopressor) considerations

- Bronchoconstriction
- Heart block

4

Esmolol (brevibloc) MOA

B1 blocker

5

Esmolol (Brevibloc) infusion dose

1-15 mg/min
50-500 mcg/kg/min

6

Esmolol (brevibloc) bolus dose

10-20 mg

7

Esmolol (brevibloc) loading dose

500 mcg/kg over 1 minute

8

Esmolol (brevibloc) considerations

PONV

9

Labetalol (normodyne) MOA

a1 blocker
B1 & B2 blocker

10

Labetalol (normodyne) infusion dose range

0.25 - 1.0 mg/kg

11

Labetalol (normodyne) bolus dose

5-20 mg q 5-10 min

12

Labetalol (normodyne) considerations

Beta:alpha = 7:1
Max = 300 mg

13

Nitroprusside (nipride) MOA

direct NO donor - arterial and venous

14

Nitroprusside (nipride) infusion dose range

0.1-0.5 mcg/kg/min

15

Nitroprusside (nipride) bolus dose

20-40 mcg

16

nitroprusside (Nipride) considerations

Cyanide
Max dose = 10 mcg/kg/min

17

Nitroglycerin (Nitrol) with MOA

Vasodilator, venous>arterial

18

Nitroglycerine (Nitrol) infusion dose range

5-200 mcg/min
0.1-1.5 Mcg/kg/min

19

Nitroglycerine (Nitrol) bolus dose

10-20 mcg
(give 5-10 mcg/min)

20

Nitroglycerin (Nitrol) considerations

Hypotension

21

Nicardipine (Cardene) MOA

Ca Channel blocker
Dihydropyridine

22

Nicardipine (Cardene) infusion dose range

5-25 mg/hr

23

Nicardipine (Cardene) bolus dose

None

24

Nicardipine (Cardene) considerations

Reflex tachycardia

25

Hydralazine (Apresoline) MOA

Vasodilator (arterial > venous)

26

Hydralazine (apresoline) bolus dose

2.5-20 mg IV q 4 hours

27

Hydralazine (apresoline) considerations

Max = 40 mg dose
Reflex tachycardia
Caution with CAD patients

28

metoprolol (Lopressor)concentration

1 mg/ml

29

Metoprolol (Lopressor) onset

2-5 min

30

Metoprolol (Lopressor) duration

6-12 hours

31

Metoprolol (Lopressor) metabolization:elimination

Hepatic:Renal

32

Betablocker effects

Decrease CO, decrease inotropy, decrease HR, decrease MAP, Labetalol: decrease SVR

33

Esmolol (Brevibloc) concentration

10 mg/ml

34

Esmolol (Brevibloc) onset

2 min

35

Esmolol (Brevibloc) duration

9-20 min

36

Esmolol (Brevibloc) metabolism:elimination

Nonspecific esterases

37

Nitroprusside (Nipride) concentrations

400 mcg/ml
100 mg:250 ml

38

Nitroprusside (Nipride) onset

39

Nitroprusside (Nipride) duration

1-10 min

40

Nitroprusside (Nipride) metabolism/elimination

RBC + Tissue, renal

41

Nitroprusside (Nipride) effects

-- MAP, -- SVR

42

Labetalol (Normodyne) concentration

5 mg/ml

43

Labetalol (Normodyne) onset

1-2 min

44

Labetalol (Normodyne) duration

2-8 hours

45

Labetalol (normodyne) metabolism/elimination

Hepatic:renal

46

Nitroglycerin (Nitrol) concentration

100 mcg/mL
25 mg/250 ml

47

Nitroglycerin (Nitrol) onset

1-2 min

48

Nitroglycerin (Nitrol) duration

3-6 hours

49

Nitroglycerin (Nitrol) metabolism/elimination

Hepatic/renal

50

Nitroglycerin (Nitrol) effects

-- preload, - MvO2

51

Nicardipine (Cardene) concentration

100 mcg/ml
25 mg/250 ml

52

Nicardipine (Cardene) onset

1-5 min

53

Nicardipine (Cardene) duration

3-6 hours

54

Nicardipine (Cardene) metabolism:elimination

Hepatic:renal

55

Nicardipine (Cardene) effects

-- MAP, -- SVR

56

Hydralazine (apresoline) concentration

20 mg/mL

57

Hydralazine (apresoline) onset

5-20 min

58

Hydralazine (apresoline) duration

4-8 hours

59

Hydralazine (apresoline) metabolism:elimination

Hepatic:renal

60

Hydralazine (apresoline) effects

- MAP: - SVR
- PVR