IV Anesthetic Agents Flashcards Preview

Clinical Pharm > IV Anesthetic Agents > Flashcards

Flashcards in IV Anesthetic Agents Deck (73):
1

Propofol class

Sedative hypnotic

2

Propofol MOA

GABA-A

3

Propofol intubating dose

1-3 mg/kg

4

Propofol bolus dose

10-50 mg

5

Propofol infusion dose

50-300 mcg/kg/min

6

Etomidate class

Non-barb. Hypnotic

7

Etomidate MOA

GABA-A

8

etomidate intubating dose

0.2-0.4 mg/kg

9

Etomidate considerations (4)

Decrease CMRO2
Decrease CBF
Causes adrenal suppression
Cardiac stability

10

Ketamine class

Dissociative anesthetic

11

Ketamine MOA

NMDA antagonist

12

Ketamine IV intubating dose

0.5-2 mg/kg

13

Ketamine IM intubating dose

4-10 mg/kg

14

Ketamine bolus dose

10-30 mg

15

Ketamine considerations

- bronchodilator
- Increase HR, BP, CO

16

Thiopental class

Barb

17

Thiopental MOA

GABA-A

18

Thiopental intubating dose

3-5 mg/kg

19

Thiopental considerations (3)

Decrease CMRO2
Decrease CBF
-- BP

20

Methohexital class

Barb

21

Methohexital MOA

GABA-A

22

Methohexital intubating dose

1-2 mg/kg

23

Methohexital considerations

Apnea
Eye block: cardioversion

24

Remifentanil class

Opiate

25

Remifentanil MOA

Mu agonist

26

Remifentanil intubating dose

0.5-1 mcg/kg/min - intubate after 8 min

27

Remifentanil drip dose

0.02-0.2 mcg/kg/HR

28

Remifentanil considerations

Dose IBW for obese patients

29

Precedex MOA

Alpha 2 agonist

30

Precedex intubating dose

0.5-1.0 mcg/kg over 10-30 minutes

31

Precedex drip rate

0.2-1.0 mcg/kg/hr

32

Precedex considerations

Causes sedation without respiratory depression

33

Propofol concentration

10 mg/ml

34

Propofol onset

30-60 sec

35

Propofol duration

2-8 minutes

36

Propofol metabolism

Liver/kidney

37

Propofol T 1/2

1-2 hours

38

Propofol adverse effects

Decreased BP, HR, contractility, PRIS

39

Etomidate concentration

2 mg/ml

40

Etomidate onset

60 seconds

41

Etomidate duration

3 min

42

Etomidate metabolism

Liver:kidney

43

Etomidate T 1/2

3-5 hours

44

Etomidate adverse effects

PONV
Myoclonus

45

Ketamine concentrations

50 mg/ml

46

Ketamine onset

60 sec

47

Ketamine duration of action

5-10 min

48

Ketamine metabolism

Liver

49

Ketamine T 1/2

2-3 hours

50

Ketamine adverse effects

Increased secretions
Emergence delirium

51

Thiopental concentration

25 mg/ml

52

Thiopental onset

30-60 min

53

Thiopental duration

10-30 min

54

Thiopental metabolism

Liver

55

Thiopental T 1/2

10-12 hours

56

Thiopental adverse effects

Induces CYP450
Decreases BP
No barbs in pt's with porphyrias

57

Methohexital concentration

10 mg/ml

58

Methohexital onset

30-60 min

59

Methohexital duration

5-10 min

60

Methohexital metabolism

Liver

61

Methohexital T 1/2

4 hours

62

Methohexital adverse effects

No barbs in pt's with porphyrias

63

Remifentanil concentration

50 mcg/ml

64

Remifentanil onset

60-90 seconds

65

Remifentanil duration

4-8 minutes

66

Remifentanil metabolism

RBC/Tissue esterase

67

Remifentanil T 1/2

Rapid off

68

Remifentanil adverse effects

Hyperalgesia
Apnea

69

Precedex concentration

100 mcg/ml

70

Precedex onset

5-10 min

71

Precedex metabolism

Liver/kidney

72

Precedex T 1/2

2-3 hours

73

Precedex adverse effects

Decreased HR, BP
Alpha 2: alpha 1 = 1620:1