Antiinflammatory Drugs chapter 25, 26' 35' 36 and 39

Question 0

Well absorbed from GI tract
Metabolized in liver, excreted by kidneys
Toxic to the liver
Inhibits prostaglandin synthesis (weak)
Inhibits hypothalamic heat regulating center
Well tolerated
Use with caution in patients with anemia

Answer 0

Tylenol

Question 1

Contraindications of Tylenol

Answer 1

Liver dx
Viral hepatitis
Alcoholism
Renal impairment

Question 2

Tylenol overdose

Answer 2

No more than 4000 mg day

Question 3

Anti inflammatory drugs pathophysiology

Answer 3

Inflammation - response to injury and infection

Question 4

Cardinal signs of inflammation

Answer 4

Redness
Swelling 
Heat
Pain
Loss of function

Question 5

Chemical mediator of interest in anti inflammatory drugs

Answer 5

Prostaglandin

Question 6

Antiinflammstory drug groups

Answer 6

NSAIDs

Corticosteroids

Question 7

Aspirin action

Answer 7

Antiinflsmmstory, anti platelet, antipyretic effect

Question 8

Aspirin pharmakinetics

Answer 8

Well absorbed from GI tract

Question 9

Aspirin caution

Answer 9

Do not take with other NSAIDs (decreases effectiveness of other NSAID)
Avoid during third trimester
Do not give to children

Question 10

Common side effect of aspirin

Answer 10

Gastric distress

Question 11

Patient care plan

Answer 11

Assess for allergy/sensitivity, pain, inflammation and fever
Nursing diagnosis - alteration in comfort
Plan - administer med as directed with food

Question 12

Para-chlorobenzoic acid

Answer 12

Indocin
Tolectin
Highly protein bound
Very irritating
May cause sodium and water retention and raise BP

Question 13

Phenylactic-acid derivatives

Answer 13

Voltaren
No antipyretic effects
New topical form -lower risk of GI effects with equal efficacy

Question 14

Toradol

Answer 14

First injectable

Question 15

Propionic acid derivatives

Answer 15

Ibuprofens
Brand/trade name - Motrin, Advil, nuprin, medipren
Highly protein bound
Drug interactions - increase effects of warfarin, Sulfonamides, certain

Question 16

Cox-2

Answer 16

Inflammation and pain
Drug agents Celebrex, relafen,
Contraindicated in patients with salicylate

Question 17

NSAIDs in older adults

Answer 17

Assess GI status, renal function, and bp

Prescribed nsaid dose may need to be decreased

Question 18

Steroids

Answer 18

Used frequently as an anti inflammatory agent

Not the drug of choice for arthritis due to many side effects

Question 19

DMARDS

Answer 19

Immunosuppressive agents
Cancer suppressants Imuran, cytoxan, methotrexate
Immunomodulators
Interleukin receptor antagonists

Question 20

Gout

Answer 20

The dx of kings

Disorder of uric acid and purine metabolism

Question 21

Antiinflammstory gout drug

Answer 21

Colchacine and newest colcrys