Antipsychosis

Question 1

Effects of low in dopamine

Answer 1

EPS

Weight gain

Question 2

Major tranquilizers or neuroleptic drugs

Answer 2

Antipsychotic drugs

Question 3

Class of antipsychotics that blocks d2 receptor only

Answer 3

Traditional

Question 4

Class of antipsychotic drugs that blockes d2 and serotonin receptors

Answer 4

Non traditional

Question 5

Arrange potency of antipsychotics

Answer 5

Butyrophenones = piperazine derivatives > piperidine > thioxanthenes&raquo_space; aliphatics

Question 6

About equally potent in d2 and serotonin blocking

Answer 6

Risperidone

Question 7

Active metabolite of risperidone

Answer 7

Paliperidone

Question 8

More potent as an antagonist of serotonin

Answer 8

Olanzapine

Question 9

Partial agonist effect at d2 and 5ht1a receptors

Answer 9

Aripiprazole

Question 10

Adverse effect of alpha adrenergic block

Answer 10

Orthostatic hypotention, failure to ejaculate, i potence

Question 11

Dopamine receptor block

Answer 11

Extrapyramidal effects

Question 12

Extrapyramidal side effects

Answer 12

Akathisia (uncontrolled restless ness)
Acute dystonia (spastic retrocollis/torticollis)
Parkinson’s syndrome

Question 13

Dopamine receptor hypersensitivity

Answer 13

Tardive dyskinesia (abnormal choreoathetoid movements)

Question 14

Prototype atypucal antipsychotic drug

Answer 14

Clozapine

Question 15

The only atypical agent that is EPS free and TD (tardive dyskinesia free)

Answer 15

Clozapine

Question 16

Reserved as last line due to risk of fatal and need for frequent laboratory testing

Answer 16

Clozapine

Question 17

Long acting, depot antipsychotics (IM)

Answer 17

Fluphenazine, haloperidol decanoate

Question 18

Theraphy for non compliant antipsychosis

Answer 18

Give long acting, depot antipsychosis if NR
Give clozapine if NR
Give addition of mood stab

Question 19

Proven effective for refractory patients (antipsychotic)

Answer 19

Clozapine

Question 20

Augmentation therapy of antipsychosis

Answer 20

Addition of mood stabilizing agents

Question 21

General adverse effects of antipsychotics

Answer 21

Alpha adrenergic block
Dopaminergic block
Muscarinic block

Question 22

Uncontrolled restlessness

Answer 22

Akathisia

Question 23

Spastic retrocollis/ torticollis

Answer 23

Acute dystonia

Question 24

Abnormal choreoathetoid movement

Answer 24

Tardive dyskinesia

Question 25

AE seizures

Answer 25

Clozapine

Question 26

AE agranulocytosis

Answer 26

Clozapine

Question 27

AE cardiotoxicity

Answer 27

Thioridazine, ziprasidone, clozapine

Question 28

AE Qt prolongation

Answer 28

Thioridazine, thioziprasidone

Question 29

AE myocarditis

Answer 29

Clozapine

Question 30

AE corneal deposit

Answer 30

Clorpromazine

Question 31

Lens deposit

Answer 31

Chlorpromazine

Question 32

AE retnal deposit

Answer 32

Thioridazine

Question 33

AE browning of the vision

Answer 33

Thioridazine

Question 34

Increase risk of DM

Answer 34

Olanzapine

Question 35

For tx of + symptoms

Answer 35

Typical and atypical antipsychosis

Question 36

For tx of - sympt

Answer 36

Atypical

Question 37

Neuroleptanesthesia

Answer 37

Droperidol + fentanyl

Question 38

Common complication due to long term use of antipsychotics

Answer 38

Tardive dyskinesia

Question 39

Restless leg syndrome

Answer 39

Akathisia

Question 40

Abnormal movement of any body part (face, tongue, shoulders, hips, extremities)

Answer 40

Tardive dyskinesia

Question 41

Pill rolling with fingers, limb rigidity, shuffling gait, bradykinesia

Answer 41

Pseudo parkinsonism

Question 42

Sudden muscular spasm of the face, neck back eyes and tongue

Answer 42

Acute dystonia

Question 43

Neck twisted to the side

Answer 43

Torticollis

Question 44

Neck pulled back

Answer 44

Retrocollis

Question 45

Clenched jaw

Answer 45

Trismus

Question 46

Fixed upward gaze

Answer 46

Oculogyric crisis

Question 47

Rare, idiosyncrathic reaction caused by dopamine blockage

Answer 47

Neuroleptic malignant syndrome

Question 48

T/F traditional agents block dopamine receptors, whereas non trad block serotonin receptors to a higher degree

Answer 48

T

Question 49

T/F non trad have less EPS than the traditional agents

Answer 49

T

Question 50

T/F non trad tx negative symptoms better than trad

Answer 50

T

Question 51

T/F high potency antipsychotics are favored due to lesser adverse effects

Answer 51

T

Question 52

T/F dopamine inhibits prolactin release

Answer 52

T

Question 53

T/F low potency agents are more likely to cause EPS

Answer 53

F

Question 54

T/F high potency agents more commonly produce anticholinergic effects, sedstion, and cardio side effects

Answer 54

F

Question 55

Effects of high in dopamine

Answer 55

Psychosis Inhibits prolactin secretion Decreased apetite