Antipsychosis Flashcards Preview

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Flashcards in Antipsychosis Deck (55):
1

Effects of low in dopamine

EPS
Weight gain

2

Major tranquilizers or neuroleptic drugs

Antipsychotic drugs

3

Class of antipsychotics that blocks d2 receptor only

Traditional

4

Class of antipsychotic drugs that blockes d2 and serotonin receptors

Non traditional

5

Arrange potency of antipsychotics

Butyrophenones = piperazine derivatives > piperidine > thioxanthenes >> aliphatics

6

About equally potent in d2 and serotonin blocking

Risperidone

7

Active metabolite of risperidone

Paliperidone

8

More potent as an antagonist of serotonin

Olanzapine

9

Partial agonist effect at d2 and 5ht1a receptors

Aripiprazole

10

Adverse effect of alpha adrenergic block

Orthostatic hypotention, failure to ejaculate, i potence

11

Dopamine receptor block

Extrapyramidal effects

12

Extrapyramidal side effects

Akathisia (uncontrolled restless ness)
Acute dystonia (spastic retrocollis/torticollis)
Parkinson's syndrome

13

Dopamine receptor hypersensitivity

Tardive dyskinesia (abnormal choreoathetoid movements)

14

Prototype atypucal antipsychotic drug

Clozapine

15

The only atypical agent that is EPS free and TD (tardive dyskinesia free)

Clozapine

16

Reserved as last line due to risk of fatal and need for frequent laboratory testing

Clozapine

17

Long acting, depot antipsychotics (IM)

Fluphenazine, haloperidol decanoate

18

Theraphy for non compliant antipsychosis

Give long acting, depot antipsychosis if NR
Give clozapine if NR
Give addition of mood stab

19

Proven effective for refractory patients (antipsychotic)

Clozapine

20

Augmentation therapy of antipsychosis

Addition of mood stabilizing agents

21

General adverse effects of antipsychotics

Alpha adrenergic block
Dopaminergic block
Muscarinic block

22

Uncontrolled restlessness

Akathisia

23

Spastic retrocollis/ torticollis

Acute dystonia

24

Abnormal choreoathetoid movement

Tardive dyskinesia

25

AE seizures

Clozapine

26

AE agranulocytosis

Clozapine

27

AE cardiotoxicity

Thioridazine, ziprasidone, clozapine

28

AE Qt prolongation

Thioridazine, thioziprasidone

29

AE myocarditis

Clozapine

30

AE corneal deposit

Clorpromazine

31

Lens deposit

Chlorpromazine

32

AE retnal deposit

Thioridazine

33

AE browning of the vision

Thioridazine

34

Increase risk of DM

Olanzapine

35

For tx of + symptoms

Typical and atypical antipsychosis

36

For tx of - sympt

Atypical

37

Neuroleptanesthesia

Droperidol + fentanyl

38

Common complication due to long term use of antipsychotics

Tardive dyskinesia

39

Restless leg syndrome

Akathisia

40

Abnormal movement of any body part (face, tongue, shoulders, hips, extremities)

Tardive dyskinesia

41

Pill rolling with fingers, limb rigidity, shuffling gait, bradykinesia

Pseudo parkinsonism

42

Sudden muscular spasm of the face, neck back eyes and tongue

Acute dystonia

43

Neck twisted to the side

Torticollis

44

Neck pulled back

Retrocollis

45

Clenched jaw

Trismus

46

Fixed upward gaze

Oculogyric crisis

47

Rare, idiosyncrathic reaction caused by dopamine blockage

Neuroleptic malignant syndrome

48

T/F traditional agents block dopamine receptors, whereas non trad block serotonin receptors to a higher degree

T

49

T/F non trad have less EPS than the traditional agents

T

50

T/F non trad tx negative symptoms better than trad

T

51

T/F high potency antipsychotics are favored due to lesser adverse effects

T

52

T/F dopamine inhibits prolactin release

T

53

T/F low potency agents are more likely to cause EPS

F

54

T/F high potency agents more commonly produce anticholinergic effects, sedstion, and cardio side effects

F

55

Effects of high in dopamine

Psychosis
Inhibits prolactin secretion
Decreased apetite