Autacoids Flashcards Preview

Pharmacology > Autacoids > Flashcards

Flashcards in Autacoids Deck (41):
1

Ions link to histamine release

Calcium

2

Physiologic antagonist during histamine release

Epinephrine

3

Tx for histamine release

Epinephrine, mast cell stabilizers, bronchodilators

4

Mast cells stabilizers

Chromolym sodium (nasalchrom)
Nedrocromil sodium (tilade)

5

1st gen H1 overdose

Atropine like effects

6

2nd gen H2 overdose

Cardiac arrhythmias

7

DI for antihistamines H1

Drugs that inhibit cyp3A4 (antimicrobials)
Cns depressants

8

1st generation drugs

Ethanolamines
Ethylenediamines
Piperazine
Alkylamines
Phenothiazine
Dibenzoclycoheptenes

9

2nd generation H1 antihistamines

Piperidines
Cetirizine
Acrivastine

10

Ethanolamines drugs

Carbinoxamine
Dimenhydrinate
Diphenhydramine
Doxylamine

11

Ethylenediamine drugs

Pyrilamine
Tripelennamine

12

Piperazine drugs

Hydroxyzine
Cyclizine
Meclizine

13

Alkylamine drugs

Brompheniramine
Chlorpheniramine

14

Phenothiazine drugs

Promethazine

15

Dibenzocycloheptenes

Cryoheptadine

16

Piperidines

Astemizole
Fexofenadine
Terfenadine
Loratadine

17

H1 antihist with serotonin blocking action

Cyproheptadine

18

H1 antihist with possible teratogenic effects

Piperazine drugs (hydroxyzine, cyclizine, meclizine)

19

H2 blocker with most side effect

Cimetidine

20

H2 antagonist safest

Famotidine

21

H2 blocker that binds to androgen receptors, effects?

Cimetidine, gynecomastia, galactorrhea

22

Effects of 5ht1

Vasoconstriction, behavioral actions increase happiness

23

Effects of 5ht2

Vasoconstriction

24

Effects of 5ht3

Vasoconstriction, anti-emetic, antidiarrheals

25

Effects of 5ht4

Anticonstipation

26

5ht1a agonists

Buspirone

27

5ht2 agonist

Ergot alkaloids (ergotamine, lysergic acid diethylamide)

28

5ht3 agonist

None

29

5ht4 agonist

Cisapride, tegaserod

30

5ht3 antagonist

Ondansetron, granisetron, dolasetron, cyproheptadine

31

5ht2 antagonist

Ketanserin, ritanserin

32

PGE1 analogs

Alprostadil, misoprostol

33

PGE2 analogs

Dinoprostone

34

PGF2a analogs

Carboprost
Dinoprost tromethamine
Latanoprost

35

PGI2 analog

Prostacyclin

36

Inhibits phospholipase A2

Glucocorticoids

37

Inhibitors of cox

Nsaids

38

Inhibits lipoxygenase

Zilueton

39

Leukotriene antagonist

Montelukast, zafirlukast,

40

Effects of leukotrienes

Bronchoconstriction. Edema. Increase mucus. Increase bronchial activity.

41

Triple response skin due to histamine

Reddening (local vasodilation)
Wheal formation (capillary permeability)
Flare formation (irritation of sensory nerve endings)