Autacoids

Question 1

Ions link to histamine release

Answer 1

Calcium

Question 2

Physiologic antagonist during histamine release

Answer 2

Epinephrine

Question 3

Tx for histamine release

Answer 3

Epinephrine, mast cell stabilizers, bronchodilators

Question 4

Mast cells stabilizers

Answer 4

Chromolym sodium (nasalchrom) 
Nedrocromil sodium (tilade)

Question 5

1st gen H1 overdose

Answer 5

Atropine like effects

Question 6

2nd gen H2 overdose

Answer 6

Cardiac arrhythmias

Question 7

DI for antihistamines H1

Answer 7

Drugs that inhibit cyp3A4 (antimicrobials)

Cns depressants

Question 8

1st generation drugs

Answer 8

Ethanolamines
Ethylenediamines
Piperazine
Alkylamines
Phenothiazine
Dibenzoclycoheptenes

Question 9

2nd generation H1 antihistamines

Answer 9

Piperidines
Cetirizine
Acrivastine

Question 10

Ethanolamines drugs

Answer 10

Carbinoxamine
Dimenhydrinate
Diphenhydramine
Doxylamine

Question 11

Ethylenediamine drugs

Answer 11

Pyrilamine

Tripelennamine

Question 12

Piperazine drugs

Answer 12

Hydroxyzine
Cyclizine
Meclizine

Question 13

Alkylamine drugs

Answer 13

Brompheniramine

Chlorpheniramine

Question 14

Phenothiazine drugs

Answer 14

Promethazine

Question 15

Dibenzocycloheptenes

Answer 15

Cryoheptadine

Question 16

Piperidines

Answer 16

Astemizole
Fexofenadine
Terfenadine
Loratadine

Question 17

H1 antihist with serotonin blocking action

Answer 17

Cyproheptadine

Question 18

H1 antihist with possible teratogenic effects

Answer 18

Piperazine drugs (hydroxyzine, cyclizine, meclizine)

Question 19

H2 blocker with most side effect

Answer 19

Cimetidine

Question 20

H2 antagonist safest

Answer 20

Famotidine

Question 21

H2 blocker that binds to androgen receptors, effects?

Answer 21

Cimetidine, gynecomastia, galactorrhea

Question 22

Effects of 5ht1

Answer 22

Vasoconstriction, behavioral actions increase happiness

Question 23

Effects of 5ht2

Answer 23

Vasoconstriction

Question 24

Effects of 5ht3

Answer 24

Vasoconstriction, anti-emetic, antidiarrheals

Question 25

Effects of 5ht4

Answer 25

Anticonstipation

Question 26

5ht1a agonists

Answer 26

Buspirone

Question 27

5ht2 agonist

Answer 27

Ergot alkaloids (ergotamine, lysergic acid diethylamide)

Question 28

5ht3 agonist

Answer 28

None

Question 29

5ht4 agonist

Answer 29

Cisapride, tegaserod

Question 30

5ht3 antagonist

Answer 30

Ondansetron, granisetron, dolasetron, cyproheptadine

Question 31

5ht2 antagonist

Answer 31

Ketanserin, ritanserin

Question 32

PGE1 analogs

Answer 32

Alprostadil, misoprostol

Question 33

PGE2 analogs

Answer 33

Dinoprostone

Question 34

PGF2a analogs

Answer 34

Carboprost Dinoprost tromethamine Latanoprost

Question 35

PGI2 analog

Answer 35

Prostacyclin

Question 36

Inhibits phospholipase A2

Answer 36

Glucocorticoids

Question 37

Inhibitors of cox

Answer 37

Nsaids

Question 38

Inhibits lipoxygenase

Answer 38

Zilueton

Question 39

Leukotriene antagonist

Answer 39

Montelukast, zafirlukast,

Question 40

Effects of leukotrienes

Answer 40

Bronchoconstriction. Edema. Increase mucus. Increase bronchial activity.

Question 41

Triple response skin due to histamine

Answer 41

``` Reddening (local vasodilation) Wheal formation (capillary permeability) Flare formation (irritation of sensory nerve endings) ```