Parkinson's Disease

Question 1

Other term for parkinsonism

Answer 1

Paralysis agitans, shaking palsy

Question 2

Cardinal signs of parkinsons

Answer 2

TRAP
Tremor at rest
Rigidity
Akinesia or bradykinesia
Postural instability

Question 3

Drugs that induces parkinsonism

Answer 3

Antipsychotics
Anit-emetics
Reserpine

Question 4

Drugs that reduces parkinsonism

Answer 4

Dopamine precursor
Dopamine agonist
COMT inhibitors
MAOB inhibitors
Antimuscarinic drugs
Amantadine

Question 5

Rhythmic oscillatory movement around a joint

Answer 5

Tremors

Question 6

Types of tremors

Answer 6

Resting tremors
Postural tremors
Intention tremors

Question 7

Irregular, unpredictable, involuntary muscle jerks that occurs in different parts of the body and impair voluntary activity

Answer 7

Chorea

Question 8

Sudden coordinated abnormal movement that occurs repetitively

Answer 8

Tics

Question 9

Abnormal movements that are slow and writhing in character

Answer 9

Athetosis

Question 10

Characterized by a variety of abnormal bizarre movement

Answer 10

Tardive dyskinesia

Question 11

Most common complication of long term anti psychotic treatment

Answer 11

Tardive dyskinesia

Question 12

Sustained abnormal movements cause by involuntary contraction of muscles

Answer 12

Dystonia

Question 13

I-isomer of dopa

Answer 13

Levodopa

Question 14

Natural precursor of all catecholamines

Answer 14

DOPA

Question 15

T/F L- dopa can cross BBB while dopamine can’t

Answer 15

T

Question 16

Combination dose give in combined levodopa and carbidopa

Answer 16

Ratio 1:4 (25/100mg) or 1:10 (10/100mg)

Question 17

Ethyl ester pro drug of levodopa

Answer 17

Etilevodopa

Question 18

T/F GI side effect is less common for combined levodopa and carbidopa

Answer 18

T

Question 19

Adjunct tx for carbidopa/levodopa theraphy

Answer 19

Dopamine agonist

Question 20

Peripheral dopa decarboxylase inhibitor

Answer 20

Carbidopa

Question 21

It helps increases the bioavailability of levodopa

Answer 21

Carbidopa

Question 22

Metaboliteof selegiline

Answer 22

Desmethyl-selegiline

Question 23

Used in patients experiencing wearing off phenomenon

Answer 23

Selegiline

Question 24

Orally disintegrating tablet, freeze dried absorbed through oral mucosa

Answer 24

Zydis selegiline

Question 25

Vascular cutaneous reaction charc by reddish purple fishnet-patterned mottling of the upper and lower extremities

Answer 25

Amantadine

Question 26

Subcutaneous injection effective for temporary relieving offline eriod of akinesia patients on optimized dopamine theraphy

Answer 26

Apomorphine

Question 27

Slow progressive degenerative neurologic disorder of muscle movement

Answer 27

Parkinsonism

Question 28

Antiviral agent used for prophylaxis and tx of imfluenza

Answer 28

Amantadine

Question 29

Also acailble in liquid preparation for patients with dysphagia

Answer 29

Amantadine