Parkinson's Disease Flashcards Preview

Pharmacology > Parkinson's Disease > Flashcards

Flashcards in Parkinson's Disease Deck (29):
1

Other term for parkinsonism

Paralysis agitans, shaking palsy

2

Cardinal signs of parkinsons

TRAP
Tremor at rest
Rigidity
Akinesia or bradykinesia
Postural instability

3

Drugs that induces parkinsonism

Antipsychotics
Anit-emetics
Reserpine

4

Drugs that reduces parkinsonism

Dopamine precursor
Dopamine agonist
COMT inhibitors
MAOB inhibitors
Antimuscarinic drugs
Amantadine

5

Rhythmic oscillatory movement around a joint

Tremors

6

Types of tremors

Resting tremors
Postural tremors
Intention tremors

7

Irregular, unpredictable, involuntary muscle jerks that occurs in different parts of the body and impair voluntary activity

Chorea

8

Sudden coordinated abnormal movement that occurs repetitively

Tics

9

Abnormal movements that are slow and writhing in character

Athetosis

10

Characterized by a variety of abnormal bizarre movement

Tardive dyskinesia

11

Most common complication of long term anti psychotic treatment

Tardive dyskinesia

12

Sustained abnormal movements cause by involuntary contraction of muscles

Dystonia

13

I-isomer of dopa

Levodopa

14

Natural precursor of all catecholamines

DOPA

15

T/F L- dopa can cross BBB while dopamine can't

T

16

Combination dose give in combined levodopa and carbidopa

Ratio 1:4 (25/100mg) or 1:10 (10/100mg)

17

Ethyl ester pro drug of levodopa

Etilevodopa

18

T/F GI side effect is less common for combined levodopa and carbidopa

T

19

Adjunct tx for carbidopa/levodopa theraphy

Dopamine agonist

20

Peripheral dopa decarboxylase inhibitor

Carbidopa

21

It helps increases the bioavailability of levodopa

Carbidopa

22

Metaboliteof selegiline

Desmethyl-selegiline

23

Used in patients experiencing wearing off phenomenon

Selegiline

24

Orally disintegrating tablet, freeze dried absorbed through oral mucosa

Zydis selegiline

25

Vascular cutaneous reaction charc by reddish purple fishnet-patterned mottling of the upper and lower extremities

Amantadine

26

Subcutaneous injection effective for temporary relieving offline eriod of akinesia patients on optimized dopamine theraphy

Apomorphine

27

Slow progressive degenerative neurologic disorder of muscle movement

Parkinsonism

28

Antiviral agent used for prophylaxis and tx of imfluenza

Amantadine

29

Also acailble in liquid preparation for patients with dysphagia

Amantadine