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Flashcards in Persons Deck (23):
1

Practical experience and theory in pcol

Claudius galen

2

Rational use of drugs

Claudius galen

3

Active ingredients in prescribed medicine

Theophrastus von hohenheim

4

Poisoner

Theophrastus von hohenheim

5

All subs are poison except for the right dose

Theophrastus von hohenheim

6

Animal experiments about pcol and toxi

Johann jakob wepfer

7

First institution of pharmacology

Rudolf buchheim, at univ of dorpat (estonia)

8

Chemical properties of drugs

Rudolf buchheim

9

Father of modern pcol

Oswald schmiedeberg

10

1st journal pcol

Archiv for experimental pathology and pharmacology

11

1st journal pcol who

Oswald schmiedeberg, bernhard naunyn, edwin klebs

12

SAR

Thomas richard frazer

13

Drug receptor

J. Langley

14

Selective toxicity

Paul ehrlich

15

First formalized receptor theory

Alexander j. Clark

16

Apply law of mass action to drug-receptor interactions

Alexander j. Clark

17

Father of modern american pharmacology

John j. Abel

18

Founder of journal or pharmacology and experimental therapeutics

John j. Abel

19

Theoretical background of pcol

Claudius galen

20

theory: pcol effect depends on the percentage of receptors occupied, affinity

Hypothesis of clark

21

Theory: occupational, effectivenes lasts as long as the receptor is occupied, affinity and intrinsic activity

Theory of ariëns and stephenson

22

Theory: rate, effectivenes does not depend upon actual occupation of the recotor but upon obtaining the proper stimulus only

Hypothesis of paton

23

Theory: drug molecule must fit into the receptor

Lock and key theory