Antiviral Drugs Flashcards Preview

Pharmacotherapeutics I > Antiviral Drugs > Flashcards

Flashcards in Antiviral Drugs Deck (17):
1

Why are viruses hard to treat?

Effective tx requires that the drug must enter the host cell
Most antivirals agents inhibit single steps in viral replication and are virusatic

2

Inhibitors of viral attachment, uncoating or release

Pleconaril
Docosanol
Amantadine
Rimantadine
Osteltamivir
Zanamivir

3

Amantadine and Rimatadine- Inhibitors of Viral Attachment

Bind viral protein M2 and inhibit viral uncoating
Used to tx and prophylaxis of influenza type A, no effect on type B-lack M2
Large volume distribution
Amatadine-90% excreted unchanged in urine (used in parkinson's disease)
Rimantadine- metabilized by the liver

4

Neuraminidase Inhibitors- Oseltamivir and Zanamivir

Selective inhibitors of viral neuraminidases which are essential for release of virus from the infected cell.
Tx of influenza A and B, duration 5 days
Prophylaxis before or after exposure to influenza A or B
Oseitamivir- oral
Zanamivir- intranasal or inhalation of dry powder

5

Inhibit attachment- Pleconaril

Prevents attachment of the virus and viral uncoating within the human cell
Effective against picornavirus- not FDA approved

6

Inhibit attachment- Docasanol

Prevents attachment of the virus to the human cell
OTC cream- recurrent oral/genital herpes

7

Drugs that block DNA synthesis from Viral DNA

Active against herpes family of viruses
Guanosine analogs- acyclovir, valacyclovir, penciclovir, famiciclovir, ganciclovir
Adenosine analog- vidarabine
Cytosine analog- cidfovir

8

Drugs that block DNA synthesis from viral DNA- Acyclovir, valacyclovir, penciclovir, ganciclovir, valganciclovir

Phosphorylated by viral thymidine kinase
Mechanism of viral resistance
Antiviral activity limited to replicating viruses

9

Acyclovir and Valacyclovir (oral prodrug of acyclovir)

Tx and prophylaxix prevention of herpes simplex (type I and II), and zoster
Varicella zoster- treatment

10

Drugs that block DNA synthesis from viral DNA- penciclovir and Famciclovir (oral prodrug of penciclovir)

Used to tx herpes zoster, herpes simplex Type II, topical tx of oral/labial herpes simplex virus

11

Drugs that block DNA synthesis from viral DNA- acyclovir and penciclovir

Pregnancy category B

12

Drugs that block DNA synthesis from viral DNA- Ganciclovir and Valganciclovir (oral prodrug)

Active against all herpes virus
Tx of CMV in immunocompromised patients
Neutropenia, thrombocytopenia, teratogenic- catergory C
Vitasert- an intraocular sustained release implant for CMV retinitis.

13

Drugs that block DNA synthesis from viral DNA- vidarabine

Broad spectrum antiviral activity- herpes, pox viruses, rhabdoviruses, hepadenaviruses, some RNA tumor viruses
Primary use- keratitis, keratoconjunctivitis, life threatening herpes simplex virus, varicella zoster infections
Side effects- N/V, bone marrow suppression, neurotoxicity, peripheral neuropathy.

14

Drugs that block DNA synthesis from viral DNA- cidofovir

Broad spectrum antiviral activity- herpes and pox viruses, adenoviruses, papilloma viruses, and hepadenavirus
Primary use for tx of cytomegalovirus in AIDS pts who are intolerant, relapsed, or nonresponsive to ganciclovir or foscarnet
Neutropenia and nephrotoxicty

15

Drugs that block DNA synthesis from viral DNA- Foscarnet

Does not require phosphorylation- broad spectrum
Active against all herpes viruses, influenza, and HIV
Primary uses- CMV (cytomegalvirus) infections, acyclovir, resistant herpes simplex or varicella zoster
Nephrotoxicty

16

Drugs that block DNA synthesis from viral DNA- Ribarvirin

Purine nucledoside analog
Ribavirin aerosol treatment of RSV
Ribavirin plus pegiterferon- Hep C

17

Non-specific inhibition of RNA and protein synthesis- Interferons

Immunomodulatory and antiviral
Dose limiting toxicities include- neutropenia and anemia, flu like sx, fever, fatigue, and myalgia
Interferons mainly act to prevent translation of viral proteins.