Dosing and Calculations Flashcards Preview

Pharmacotherapeutics I > Dosing and Calculations > Flashcards

Flashcards in Dosing and Calculations Deck (15):
1

Ratio

the relative magnitude of two like quantities (Ie: 20g:4g terms must be in the same units)

2

Proportion

An expression of the equality of two ratios
A/B=C/D
Ex: If 3 tablets contain 975 milligrams of aspirin, how many milligrams should be obtained in the 12 tablets? 3900

3

Inverse Proportion

If 10 pints of a 5% solution are diluted to 40 pints what is the percentage strength?
(10)(0.5)=(40)(x) is 1.25%

4

Dimensional analysis

Canceling out units
A medication order calls for 1L dextrose 10% infusion to be administered over an 8hr period. Using an IV pump set that delivers 10drops/milliliter how many drops a minute should be delivered to the patient?
1000ml/8hr X 10 drops/mL X 1hr/60 minutes = 21 drops/min

5

Metric system

1000mcg=1mg
1000mg=1g
1000g=1kg
1inch=2.54cm
1tsp=5mL
2.2lb=1kg

6

Median effective dose

Amount that produces desired intensity of effect in 50% of individuals tested

7

Median toxic dose

amount that produces toxic effects in 50% of individuals tested

8

Minimun effective concentration

Minimum dose we see working in the blood

9

Minimum toxic concentration

minimum toxic level in the blood

10

Pediatrics

Neonate- birth to 1 month
Infant- 1 month to 1 year
Early childhood- 1 year to 5 years
Late childhood- 5 years to 12 years
Adolescence- 13 years to 17 years

11

Pediatric Rx restrictions

Consider age and weight
Based on weight often expressed as mg/kg
Based on body surface area

12

Expressions of Concentrations

%w/v=grams/100mL
%v/v=mL/100mL
%w/w=grams/100grams

13

IBW

Males- IBW= 50kg + 2.3kg for each inch over 5 ft
Females- IBW= 45.5kg + 2.3kg for each inch over 5ft

14

Adjusted Body Weight

AjBW=IBW + 0.4(ABW-IBW)

15

Creatinine Clearance

Tests the functioning of the kidneys
CrCl= (140-age) x IBW / (Scr x72)
(x0.85 for females)
*if actual weight 30% obesity use adjusted
*Raise Scr to 1 if pt> 65y/o
Normal creatinine is less than 1