Pharmacodynamics Flashcards Preview

Pharmacotherapeutics I > Pharmacodynamics > Flashcards

Flashcards in Pharmacodynamics Deck (22):
1

Pharmacodynamics

The study of the biochemical and physiological effects of drugs on the body and their mechanism of action

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Receptors

Bind with the drug to produce a drug-receptor complex and and effect

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Pharmacodynamic Response

Describe the effect of the drug on the body.

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Quantal dose-response relationship

plots fraction of population that respond to give drug dose as function of dose.
Effectiveness, toxicity, and lethality

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Graded dose- response curve

Demonstrates the effect of a drug as function of its concentration.

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Efficacy

Maximal response produced by a drug

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Potency

The amount of drug needed to elicit a give response. the lower he dose required the more potent the drug.

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Slope of dose

Response curve -> steep slope ->small increase in dose produces large changes in response

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Active Receptor

Binds the drug

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Inactive receptor

unable to bind the drug

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Agonist

Binds receptors and activates

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Partial agonist

binds receptor at active site and produces only a partial response even when all the receptors are bound by the partial agonist.

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SERMS

Act as a partial agonist to estrogen receptors in bone and an antagonist to estrogen receptor in the breast

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Buprenorphine

Partial agonist with high affinity for Mu-opoid receptor maybe be more potent but less efficacious then full agonist (morphine)

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Pindolol

Often classified as a beta blocker but is actually a partial agonist that produces intermediate response.
Resting heart rate and blood pressure no reduced as well as pure antagonists, but pindolol inhibits potentially dangerous increases that would occur w/ sympathetic stimulation.

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Antagonist

Inhibits the action of an agonist. Has no effect in the absence of the agonist.

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Chemical antagonists

Inactivate agonist before it has the opportunity to act

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Physiological antagonists

cause a physiologic effect opposite to that induced by the agonist

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Competitive antagonist

Binds, reversibly to the active site of a receptor, and does not cause activation. Shifts to right

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Noncompetitive antagonist

Bind to either active or allosteric site of receptor. If bound to active site the binding is irreversible and cannot be outcompeted by agonist. Allosteric agonist acts by preventing receptor activation. Maximal efficacy of agonist is reduced.

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Therapeutic window

Range of doses of drug that elicits therapeutic response without unacceptable toxicity.

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Drug-drug interactions

Drugs w/ similar characteristics may produce an exaggerated response.
Drugs w/ opposing pharmacodynamic effects may cause a diminished or lack of response.