Flashcards in Pharmacodynamics Deck (22):
The study of the biochemical and physiological effects of drugs on the body and their mechanism of action
Bind with the drug to produce a drug-receptor complex and and effect
Describe the effect of the drug on the body.
Quantal dose-response relationship
plots fraction of population that respond to give drug dose as function of dose.
Effectiveness, toxicity, and lethality
Graded dose- response curve
Demonstrates the effect of a drug as function of its concentration.
Maximal response produced by a drug
The amount of drug needed to elicit a give response. the lower he dose required the more potent the drug.
Slope of dose
Response curve -> steep slope ->small increase in dose produces large changes in response
Binds the drug
unable to bind the drug
Binds receptors and activates
binds receptor at active site and produces only a partial response even when all the receptors are bound by the partial agonist.
Act as a partial agonist to estrogen receptors in bone and an antagonist to estrogen receptor in the breast
Partial agonist with high affinity for Mu-opoid receptor maybe be more potent but less efficacious then full agonist (morphine)
Often classified as a beta blocker but is actually a partial agonist that produces intermediate response.
Resting heart rate and blood pressure no reduced as well as pure antagonists, but pindolol inhibits potentially dangerous increases that would occur w/ sympathetic stimulation.
Inhibits the action of an agonist. Has no effect in the absence of the agonist.
Inactivate agonist before it has the opportunity to act
cause a physiologic effect opposite to that induced by the agonist
Binds, reversibly to the active site of a receptor, and does not cause activation. Shifts to right
Bind to either active or allosteric site of receptor. If bound to active site the binding is irreversible and cannot be outcompeted by agonist. Allosteric agonist acts by preventing receptor activation. Maximal efficacy of agonist is reduced.
Range of doses of drug that elicits therapeutic response without unacceptable toxicity.