Enfuvurtide?
HIV: membrane fusion
Amantadine and rimantadine?
Influenza: blocks M2 channel; prevents uncoating upon entry
What do nucleoside analogs prevent a virus from doing?
Replicating genome
Acyclovir
Herpesvirus: genome replication by blocking TK
What types of viruses does RIbavirin affect?
RNA viruses: inhibits polymerases and lowers GTP
Which antiviral blocks the cleavage of genes in HIV?
Ritonavir
Which antivirals block attachment?
- Enfuvirtide: HIV
What do cells have that natural fight viruses?
Interferons (more effective against RNA)
What antivirals block the uncoating of the virus genome in the cell?
- Amantadine (flu)
What antivirals block late protein synthesis and processing?
Protease inhibitors (HIV)
What antiviral is a neuraminidase inhibitor?
Tamiflu
Which antivirals block nucleic acid synthesis?
- NRTIs and NNRTIs (HIV)
- Acyclovir (HSV)
- Entecavir (HBV)
What is passive immunization?
Administering antibodies produced in someone else’s body. No virus given.
Which type of vaccine does not induce cell mediated immunity?
Killed
