Flashcards in Anxiety Deck (23):
What is anxiety?
Hypervigilance, physiological preparedness and negative subjective states and may share some critical neural circuits with fear.
State of preparation for danger in the absence of immediate threat.
Role of the amygdala
Key to sensing fear, may also be key for producing empathy to others peoples fear.
What is CRF?
Corticotrophin releasing factor
Acts on GRF1 and 2 GPCR
Released in central nucleus of the amygdala to produce fear
Releases glucocorticoids from the adrenal cortex (supressed inflamation heightens arousal)
-CRF receptor antagonists may have treatment potential for anxiety.
What does bed nucleus stria terminalis do?
Responds to general stimuli
Part of anxiety circuit
Larger in females
Types of anxiety disorders
Generalised anxiety disorder
Role of beta adrenergic receptor activation in emotion enhanced memories.
Activation leads to memory with associated fear. Block with propanolol in a&e
What is PTSD?
Hypervigilance, sleep distubance, nightmares cue induced reexperience, cues can be over generalised.
Treatment for PTSD?
SNRI antidepressants VENLAFAXINE and DULOXETINE
Propanolol, maintain memory without fear?
Mdma with cbt, postivie feeling recalling negative events
What is generLised anxiety disorder?
Unrealistic excessive worry for more than 6 months accompained by specific anxiety related symptoms, motor tension, hypervigilance, sympathetic hyperactivity
Treatment for generalised anxiety disorder?
Antidepressants ssris snris and benzodiazepine
Benzos produce anterograde amnesia :(
What is panic disorder?
Discrete attacks of intense anxiety accompanied by tachycardia, tachpynea and dizziness.
Treatment for panic disorder
Antidepressants snris and benzos with cbt
Benzos bind to alpha and increase gaba's affinity for beta, its hard to overdose on them but dont take with alcohol as this increases endogenous gaba
Beta gabaa subunit
Gaba binds to beta, gamma is also required
Binds alpha gabaa
Its an inverse agonist (pam) produces opposite effects to benzos,
Bind alpha, but structurally distinct to benzos.
Delta gabaa subunit
Alcohol interacts with it????
Gaba a convulsant site
Binds picrotoxin and pentylentetrazol
Barbituates bind to....
Near chloride channel
Increase frequency and duration of channel opening,
can act independently of gaba
Neurosteroid site on gabaa
Binds endogenous preganolone (sedative) released during pregnancy
Symptoms of obsessive compulsive disorder
Obsessive, intrusive throughts and ritualised behaviours
Reduce anxiety but impair normal functions
Anxiety drives compulsion but sufferes show impaired impulse control
Neurocircuitry of ocd
- similar to tourettes syndrome (abnormal striatal thalamic prefrontal cortex function)
- related to impaired impulse control and anxiety