Flashcards in Ganja Deck (10):
Where is the active ingredient found?
What is the active substance?
Thc is the psychoactive substance
Cbd is non psychoactive, but not inactive.
Acute effects of cannabis in humans
Mild euphoria to paranoia
Increased heart rate, due to vasodilation
Hallucinations at high doses
Short term memory
Link between scizophrenia and cannabis
Early cannabis uses increases risk of psychosis 2-3 fold
Is cannabis addictive?
Yes, but it less addictive than other drugs.
Animals dont like it as much as other drugs.
What receptors does cannabis bind to?
Gi pcr, decrease presynaptic neurotransmitter release
Most highly expressed gpcr in the brain (hippocampus, cerebral cortex, cerebellum, basal gang, medulla)
What is the endogenous cb1 agonist?
ANANDAMIDE, 2-ARACHIDONYL GLYCEROL
Formed from arachidonic acid membrane precursors
Not stored in vesicles
Synthesised on demand
Act to decrease neurotransmitter release
What may be a method to treat drug addiction?
Reduce cb1 activity, reduces drug and ethanol consumption
Blocking cb1= decreased ethanol self admin
Increasing the levels of intoxication
What type of cb1 receptors and anandamide metabolising enzymes are associated with human addiction?