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Flashcards in Ganja Deck (10):
0

Where is the active ingredient found?

Female plant
Cannabis sativum

1

What is the active substance?

Thc is the psychoactive substance
Cbd is non psychoactive, but not inactive.

2

Acute effects of cannabis in humans

Mild euphoria to paranoia
Increased heart rate, due to vasodilation
Incoordination
Hallucinations at high doses
Short term memory
Appetite stimulant
Analgesia
Red eyes
Sleepiness

3

Link between scizophrenia and cannabis

Early cannabis uses increases risk of psychosis 2-3 fold

4

Is cannabis addictive?

Yes, but it less addictive than other drugs.
Animals dont like it as much as other drugs.

5

What receptors does cannabis bind to?

Gi pcr, decrease presynaptic neurotransmitter release
Most highly expressed gpcr in the brain (hippocampus, cerebral cortex, cerebellum, basal gang, medulla)

6

What is the endogenous cb1 agonist?

ANANDAMIDE, 2-ARACHIDONYL GLYCEROL
Formed from arachidonic acid membrane precursors
Not stored in vesicles
Synthesised on demand
Act to decrease neurotransmitter release

7

What may be a method to treat drug addiction?

Reduce cb1 activity, reduces drug and ethanol consumption
Blocking cb1= decreased ethanol self admin
Increasing the levels of intoxication

8

What type of cb1 receptors and anandamide metabolising enzymes are associated with human addiction?

Genetic variants!

9

Treatment for drug addiction in humans?

Cb1 antagonist
But this causes depression
RIMONABANT