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Flashcards in Sezuires Deck (30):
0

Sezuires

Brief loss of conciousness
Perception of odours
Confusion
Bizare behaviours

1

Generalised sezuire

Involves both hemisoheres
Widespread synchronisation

2

Types of generalised sezuires

Absence
Atonic drop
Clonic
Myclonic
Generalised tonic clonic

3

Absence sezuire

Petit mal
Brief lapse of conciousness

4

Atonic drop

Gen
Sudden loss of posture
Brief invol muscle twitch

5

Clonic

Repetitive jerking, 1 min

6

Myoclonic

Single rapid twitch event

7

Generalised tonic clonic

Grand mal
Immediate deep loss of conciousness
Tonic phase of rigid muscle contraction
Clonic phase of violent jerking
As a consequence of focal sezuire spreading

8

Focal sezuire

Localised synchronisation in a sezuire focus
Symptoms reflect brain area they occur in
Can become generalised

9

Symptoms of focal sezuires

Deja vu
Temporal lobe epilepsy
Focal motor sezuires
Vulnerable brain areas=temporal lobe and motor cortex

10

Jacksonian sezuire

Starts in fingers, travels up arm, frontal lobe epilepsy

11

Causes of epilepsy

High fever
Head injury
Stroke
Tumour
Alcohol withdrawl
Genetic abnormalisties
Development abnorm
Chronic illness

Usually due to imbalance between excitatory and inhibitory neuronal activity

12

What can make absence epilepsies worse?

Gabaa drugs
Increase synchronisation of t type ca channels in bs

13

Whats the general treatment for partial sezuires

Gaba a levels/r or na channel drugs

Decrease excitation increase inhibition

14

Sodium channel inaxtivator

Partial sezuire treatment
Stabilises inactivated state of vg sodium channels
Reduces sustained firing of neurones
Significant side effects

15

Phenytoin

Sodium channel inactivator
Partial sezuire treatment

16

Carbamazepine

Sodium channel inactivator
Partial sezuire treatment

17

Oxcarbazepine

Sodium channel inactivator
Partial sezuire treatment

18

Iamotrigine

Sodium channel inactivator
Partial sezuire treatment

19

Topiramate

Sodium channel inactivator
Partial sezuire treatment

20

Felbamate

Sodium channel inactivator
Partial sezuire treatment

21

Gaba a enhancers

Benzos , channel open for longer, engog gaba

Phenobarbital, does not need endog gaba, limited use except in status epilepticus and refractory epilepsy

Produce tollerance, sedation, confusion and dependence

22

Diazepam

Benzo

23

Vigabatrin

Phenobarbital
Inhibit breakdown of gaba by gaba tansaminase

24

Tiagabine

Inhibits gaba uptake by gaba transporter

25

Gabapentin and pregabalin

Bind to gabars
Decrease gaba uptake
Increase gaba release
Increase gaba synthesis

26

Zonisamide

Partial sezuires
Gabaa rs inhibit reuptake

27

Levitiracetam

Cyclic gaba derivative
Unknown mech
Bind vesicle protein sva2? Inhibiting exocytosis

Bind to calcium channel to decrease neurotransmission?

28

Generalised sezuire treatment

Calcium channel blocking

29

Ethosuximide

Blocks t type ca channels that cause synchronisation in absence sezuires