Flashcards in Neurodegeneration Deck (11):
Why are o2-. And h2o2 produced normally?
By wbc for a protective function
What can excess o2-. And h2o2 lead to?
Tissue damage and production of hydroxyl radicals oh. In presence of catalytic iron ions
What is a major role of antioxidants?
Storage and transport of iron ions in forms that will not catalyse formation of reactive radicals
What does oxidative stress on ns lead to?
Increase calcium and glutamate
Where do ros come from during neurodegen?
Microglia cross bbb during pathologies that compromise bbb
Leukocytes possess both nadph oxidase and no synthase
Therapy for ad
Galantamine and rivastigmine
Non competetivenmdar antagonists
Prevents damage caused by glutamate toxicity
Converted to dopamine by dopa-decarboxylase
Acts as dopamine r agonist
Deep brain stimulation
Used in pd patients when drugs are ineffective