Neurodegeneration

Question 0

What can excess o2-. And h2o2 lead to?

Answer 0

Tissue damage and production of hydroxyl radicals oh. In presence of catalytic iron ions

Question 1

Why are o2-. And h2o2 produced normally?

Answer 1

By wbc for a protective function

Question 2

What is a major role of antioxidants?

Answer 2

Storage and transport of iron ions in forms that will not catalyse formation of reactive radicals

Question 3

What does oxidative stress on ns lead to?

Answer 3

Increase calcium and glutamate

Question 4

Where do ros come from during neurodegen?

Answer 4

Microglia cross bbb during pathologies that compromise bbb

Leukocytes possess both nadph oxidase and no synthase

Question 5

Therapy for ad

Answer 5

Galantamine and rivastigmine
Achesterase inhibitors

Memantine
Non competetivenmdar antagonists
Prevents damage caused by glutamate toxicity

Question 6

L-dopa

Answer 6

Converted to dopamine by dopa-decarboxylase

Question 7

Tolcapone

Answer 7

Inhibits catechol-o-methyltransferase

Question 8

Cabergoline

Answer 8

Acts as dopamine r agonist

Question 9

Deep brain stimulation

Answer 9

Used in pd patients when drugs are ineffective

Question 10

Therapeutics for ms

Answer 10

Natalizumab

Monoclonal antibody treatment stops leukocytes getting into brain