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Flashcards in Neurodegeneration Deck (11):
0

Why are o2-. And h2o2 produced normally?

By wbc for a protective function

1

What can excess o2-. And h2o2 lead to?

Tissue damage and production of hydroxyl radicals oh. In presence of catalytic iron ions

2

What is a major role of antioxidants?

Storage and transport of iron ions in forms that will not catalyse formation of reactive radicals

3

What does oxidative stress on ns lead to?

Increase calcium and glutamate

4

Where do ros come from during neurodegen?

Microglia cross bbb during pathologies that compromise bbb
Leukocytes possess both nadph oxidase and no synthase

5

Therapy for ad

Galantamine and rivastigmine
Achesterase inhibitors

Memantine
Non competetivenmdar antagonists
Prevents damage caused by glutamate toxicity

6

L-dopa

Converted to dopamine by dopa-decarboxylase

7

Tolcapone

Inhibits catechol-o-methyltransferase

8

Cabergoline

Acts as dopamine r agonist

9

Deep brain stimulation

Used in pd patients when drugs are ineffective

10

Therapeutics for ms

Natalizumab
Monoclonal antibody treatment stops leukocytes getting into brain