Anxiety Flashcards Preview

Physioloogy and pharmacology > Anxiety > Flashcards

Flashcards in Anxiety Deck (16)
Loading flashcards...
1

What is generalized anxiety

No clear reason or focus - interfere with normal behaviour

2

What is a panic disorder

Overwhelming fear marked somatic symptoms

3

What is the normal action of GABAa receptors

Ionotropic receptor mediating fast inhibitory transmission in the brain- found post synaptically mediating the release inward movement of chloride ions

4

How many subunits make up the channel

5 - make up influences pharmacology, location and function

5

What is an agonist at the orthosteric site of GABAaR

Muscimol

6

What is an antagonist at the orthosteric site of GABAaR

Bicuculline

7

What is an agonist at the allosteric site of GABAaR

Diazepam

8

What is an antagonist at the allosteric site of GABAaR

Flumazenil

9

How do GABAb receptors cause inhibition

Inhibit Cav presynaptically and activate Kv channels post-synaptically

10

Where do benzodiazepines bind to GABAaR

Binding site lies at the alpha - gamma interface

11

What is the common subunit assembly of GABAaR

B2,A1,B2,A1,G2

12

What is the alpha 1 subunit associated with

Sedative effect of benzodiazepines

13

What subunit is associated with anxiolytic effects

Alpha 2,3,5

14

What 4 physiological effects do benzodiazepine have

Sedation, Hypnosis, Anterograde amnesia (prevent memories while under their influence), Anti-convulsant (Inhibit development and spread of epileptiform activity

15

How do benzodiazepines interact with the allosteric site

Bind to the allosteric site of the GABAaR - Patch clamp technique revealed that the binding caused there to be an increase in open probability of the GABAaR increasing GABA affinity - without increasing the time that the channels are open for at the orthosteric site

16

What are some adverse effects of benzodiazepine agonists

1.Sleepiness, additive effects with other CNS depressants
2. Tolerance - decreased responsiveness following continued use - may be overcome with increasing dose
3. Misuse - physical dependence - increased anxiety, insomnia, CNS excitability - more of a problem with short half life drugs - drugs used for sleeping disorders may cause daytime anxiety