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Apicomplexan 3 Flashcards

1
Q

What phase of Toxoplasma gondii is the quickly proliferating intracellular stage?

A

Tachyzoite

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2
Q

Which stage of Toxoplasma gondii is the slowly proliferating stage within tissue cysts?

A

Bradyzoite

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3
Q

Which stage of Toxoplasma gondii is inhibited by the immune response?

A

Tachyzoite

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4
Q

What are the 3 GENERAL modes of transmission of Toxoplasma gondii?

A
  1. Ingested of sporulated oocyst
  2. Transplacental
  3. Intermediate host
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5
Q

Toxoplasma gondii:

Tissue cysts with _____ in an intermediate host are infective.

A

Bradyzoites

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6
Q

Toxoplasma gondii:

Transplacental transmission by _____.

A

Tachyzoites

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7
Q

What is the definitive host of Toxoplasma gondii?

A

Cat

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8
Q

What is the primary means of transmission of Toxoplasma gondii?

A

Eating tissue cysts with bradyzoites

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9
Q

Where do merogony and gametogony occur for Toxoplasma gondii?

A

ONLY in the GI tract

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10
Q

True or False:

Toxoplasma gondii infected hosts shed sporulated oocysts in their feces.

A

FALSE

Oocysts are unsporulated

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11
Q

True or False:

  1. Toxoplasma gondii has an extra-intestinal phase.
  2. Sporulation of the unsporulated oocyst occurs in the environment over a period of about 10 days.
A
  1. TRUE
  2. FALSE - sporulation takes about 1-5 days
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12
Q

What type of replication occurs in the intermediate host of Toxoplasma gondii?

A

Extra-intestinal replication

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13
Q

Toxoplasma gondii:
Cysts with bradyzoites can be found in which parts of an intermediate host’s body?

A

Eyes

Brain

Striated muscle

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14
Q

Toxoplasma gondii:
How would congenital infection occur?

A

Mother would have to be infected DURING the pregnancy, not before

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15
Q

Explain how a kitten might typically become infected with Toxoplasma gondii

A

Maternal antibody levels decline –> begin hunting –> ingest an intermediate host

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16
Q

When do cats typically shed oocysts when infected with Toxoplasma gondii?

A

Cats usually shed oocysts only ONCE in their lifetime following the primary infection

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17
Q

Why is congenital infection with Toxoplasma gondii uncommon?

A

Cats are typically exposed to Toxoplasma prior to pregnancy

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18
Q

Clinical toxoplasmosis is relatively uncommon in dogs. In what populations of dogs might it be more common?

A

The young

The immunosuppressed

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19
Q

Explain the outcome of a congenital infection of Toxoplasma gondii in a small ruminant. Why does the outcome vary?

A

Outcome varies depending on the stage of gestion when infection occurred/severity of that infection:

Early embryonic death

Fetal death and abortion

Stillbirth

Birth of weak offspring

Birth of congenitally infection normal offspring

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20
Q

Which 3 species are relatively resistant to toxoplasmosis?

A

Cattle

Horses

Camelids

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21
Q

True or False:
Toxoplasma gondii congenital infections are more severe in humans the later in gestation they occur.

A

FALSE

More severe the earlier in gestation they occur

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22
Q

Human Toxoplasma gondii infection:

What type of disease process might you see in an immune compromised individual?

A

Encephalitis

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23
Q
A

Toxoplasma gondii: unsporulated oocyst from fresh cat feces

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24
Q
A

Isosporid sporulated oocyst of Toxoplasma gondii

(NOT from fresh feces)

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25
When you have reproductive loss in a small ruminant, what type of diagnostics might you want to run for Toxoplasma gondii?
1. Check for gross lesions in placental cotyledons (multi focal grayish-white areas) 2. Anti-Toxoplasma antibodies in fetal fluid 3. Histopathology of fetal brain +/- placenta
26
1. What are 2 drugs you could use to treat Toxoplasmosis in small animals? 2. Which life cycle stage are those medications active against?
1. Clindamycin & Pyremethamine 2. Active against tachyzoites
27
What scenerio is the highest risk to humans for a Toxoplasma infection?
Seronegative human + Cat shedding oocysts
28
Which Toxoplasmosis scenerio poses the lowest risk to humans?
Seropositive human + Cat not shedding oocysts
29
How might you prevent transmission of Toxoplasma to humans?
Prevent ingestion of tissue cysts: 1. Wear gloves when handling raw meat 2. Wash hands after handling raw meat 3. Avoid unpasteurized goat milk 4. Avoid undercooked deer meat
30
Which 3 meats are at highest risk for carrying Toxoplasma?
Lamb Pork Goat (chevron)
31
How might you help prevent/control a pregnant woman who owns a cat from getting infected with Toxoplasma?
Prevent oocyst sporulation & ingestion: 1. Clean litter box daily 2. Kill oocysts in litter box with boiling water 3. Wash hands 4. Wear gloves when gardening
32
How might you help prevent/control spread of Toxoplasma to a cat?
Prevent hunting (keep indoors) Feed commercial cat food only (no raw meat) Clean litter box daily
33
How might you help prevent/control spread of Toxoplasma to a small ruminant such as a sheep?
Decrease exposure of gestating ewes to oocysts: 1. Keep cats out of feed sources 2. Keep neutered cats only 3. Minimize hunting by cats Keep only older ewes Feed ewes monensin during gestation
34
What are the only known definitive hosts of Neospora caninum?
Dogs Coyotes
35
What are some of the intermediate hosts of Neospora caninum?
Cattle Sheep Goats Horses Deer
36
True or False: Neospora caninum has an extra-intestinal phase
TRUE
37
True or False: The immune system is better at controlling a Neospora caninum infection that it is at controlling a Cryptosporidium infection.
FALSE Immune system is better at controlling a Cryptosporidium infection.
38
What are the modes of transmission for Neospora caninum?
1. Ingestion of tissue cysts with bradyzoites 2. Transplacental transfer of tachyzoites
39
How does the intermediate host for Neospora caninum become infected?
Ingestion of sporulated oocysts
40
What is THE main mode of transmission of Neospora caninum?
Transplacental transfer of tachyzoites from dam to offspring
41
True or False: 1. For Neospora caninum in dogs, merogony and gametogony occur in the intestine, similar to Toxoplasma in cats. 2. For Neospora caninum, dogs shed sporulated oocysts in their feces.
1. TRUE 2. FALSE - shed NON-sporulated oocysts in their feces, similar to oocysts of Toxoplasma
42
What causes the clinical signs associated with Neospora caninum?
Tachyzoites
43
Neospora caninum infects many cell types throughout the body, what are they?
Skin Liver CNS Muscle Kidneys
44
Which has a thicker cyst wall, Toxoplasma or Neospora caninum?
Neospora caninum
45
Neospora caninum: Tachyzoites transform to bradyzoites as a result of what?
The immune response
46
Neospora caninum: 1. What life stage forms tissue cysts? 2. In what tissue will those cysts primarily be found?
1. Bradyzoites 2. CNS
47
Which organism is associated with a recrudescence of parasitemia from chronic infection?
Neospora caninum
48
Neospora cyst
49
Toxoplasma cyst
50
Neospora caninum: 1. In cattle, there is inflammation of the placenta and fetus associated with what? 2. In dogs, abortion is associated with what?
1. Tachyzoites 2. Tachyzoites
51
What is the cause of about 20% of cattle abortions worldwide?
Bovine neosporosis
52
What is the most common outcome of bovine neosporosis?
Live normal calf with congential infection
53
Bovine vertical tranmission is believed to be related to what?
Reactivation of parasites in cysts during pregnancy --\> conversion of bradyzoites to tachyzoites --\> transplacental transmission of tachyzoites
54
Upon necropsy of a calf with bovine neosporosis, which tissue might be necrotic?
Brain Muscle Placenta
55
Is Neosporosis a zoonotic disease?
NO
56
Bovine neosporosis: 1. An endemic problem is most likely due to what? 2. An abortion outbreak is most likely due to what?
1. Endemic problem most likely due to transplacental infection 2. Abortion outbreak more likely due to transmission via contamination of feed with oocysts from canine feces
57
Hyperextension due to canine neosporosis
58
What are 2 drugs that can be used to help treat neosporosis in a pup?
Clindamycin Pyremethamine + sulfdiazine
59
What is the cause of equine protozoal myeloencephalitis? (EPM)
Sarcocystis
60
What is the definitive host for sarcocystis?
Carnivore
61
What are the intermediate hosts for sarcocystis?
Herbivore & Omnivores
62
In which host does sexual phase of sarcocystic occur?
Carnivore (definitive host)
63
In which host does the asexual phase for sarcocystis occur?
Herbivore, omnivore (intermediate host)
64
True or False: Sarcocystis species have a wide range of defintive hosts and a narrow range of intermediate hosts.
TRUE
65
How does one become infected with Sarcocystis?
Ingestion of a tissue cyst
66
True or False: Individuals with a Sarcocystic will shed sporulated oocytes in their feces.
TRUE
67
Sarcocystis: What are the 2 phases within the intermediate host?
Vascular phase Muscular phase
68
Mature cyst of Sarcocystis hominis in bovine tongue muscle Note: thick capsule consistent with Neospora + bradyzoites inside
69
Sarcocystis: What type of clinical signs are seen in the vascular phase in a herbivore?
Fever CNS disturbances Abortion Death
70
Sarcocystis: What type of clinical signs are seen in the muscular phase in a herbivore?
Myositis Myocarditis CNS signs Death
71
How does the definitive become infected with Sarcocystis?
Ingestion of bradyzoites from mature cysts in intermediate host
72
Sarcocystis: What do bradyzoites infect?
Enterocytes
73
True or False: Sarcocystis has NO proliferative phase.
TRUE
74
Where does gametogony occur for Sarcocystis?
Enterocytes of definitive host
75
True or False: 1. Sarcocystic sporocytes OR sporulated oocysts can be shed in feces. 2. Sarcocystis is immediately infective to an intermediate host in fresh feces.
1. TRUE 2. TRUE
76
Diagnosis of Sarcocystis in herbivore: 1. Detection of schizonts in ____ of major organs. 2. Detection of cysts in \_\_\_\_.
1. Detection of schizonts in **vasculature** of major organs. 2. Detect cysts in **muscle (+/- CNS).**
77
Diagnosis of Sarcocystis in a carnivore: What 2 things might you be able to indentify in fresh feces?
Sporulated oocyst (with 2 sporocytes inside) OR Free sporocyst
78
How would you control/prevent an infection with Sarcocystis?
1. Prevent dogs and cats from eating raw meat (animal carcasses) 2. Prevent contamination of herbivore feed and water with dog or cat feces
79
What the cause of equine protozoal myeloencephalitis?
Sarcocystis neurona
80
True or False: Sarcocystis neurona has a narrow definitive host range, but a broad intermediate host range/
TRUE
81
For Sarcocystis neurona, horses are the \_\_\_\_, ___ \_\_\_ host.
Aberrant, dead-end host
82
What is the ONLY definitive host for Sarcocystis neurona?
Opossum
83
What are the typical intermediate hosts for Sarcocystis neurona?
Cat Raccoon
84
1. Which host will develop tissue cysts with Sarcocystis neurona? 2. Which host will not develop tissue cysts?
1. Intermediate host = YES tissue cysts 2. Opossum & horse = NO tissue cysts
85
Asymmetric muscle atrophy + neurologic signs
Sarcocystis neurona
86
What the risk factors for Sarcocystis neurona?
1. Presence of opossums on farm 2. Presence of woods on farm 3. Occurrence of health stressor prior to signs 4. Highest in the fall 5. Increased number of horses on farm 6. Use of wood chips or shavings for bedding 7. Presence of rates, mice 8. Increased human population density
87
How would you prevent/control spread of Sarcocystis neurona on your farm?
1. Keep opossums from defecating in horse feed 2. Trap and relocate opossums 3. Remove carcasses of intermediate hosts 4. Use anti-protozoal drugs prophylactically 5. Monitor horses subjected to stress for early signs of EPM
88
Hepatozoon species: Most species that parasitize mammals infect \_\_\_.
Leukocytes
89
Hepatozoon species: Vertebrates become infected by...?
Ingesting an infected invertebrate
90
What is the transmission agent for American canine hepatozoonosis?
Amblyomma maculatum (Gulf coast tick)
91
What is the definitive host for Hepatozoon americanum?
Gulf coast tick (Amblyomma maculatum)
92
How is a dog infected with Hepatozoon americanum?
Ingestion of ticks infected with oocysts
93
Hepatozoon americanum: Canines can become the intermediate hosts. Merogony occurs in the \_\_\_\_, and early gametogony occurs in the \_\_\_\_.
Merogony occurs in the **tissues.** Early gametogony occurs in the **monocytes & macrophages.**
94
Hepatozoon americanum: 1. Tick takes up gamonts in ____ with a blood meal. 2. ____ occur in the tick hemocoel.
1. Tick takes up gamonts in **monocytes / macrophages** with a blood meal. 2. **Sporulated oocysts** occur in the tick hemocoel.
95
What do you call the cysts that form due to a Hepatozoon americanum infection in a dog?
Onion skin cysts
96
What are the clinical signs of Hepatozoon americanum in a dog?
Fever Myalgia Myasthenia Reluctance to move due to pain (due to myositis or periosteal vone proliferation) Wasting
97

Parasitology 376 (20 decks)

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