Aplastic anaemia

Question 1

What is aplastic anaemia defined by and criteria

Answer 1

Pancytopenia with hypocellular marrow and no abnormal cells
At least 2 of:
<100 Hb
platelets <50
<1.5 neutrophils

Question 2

Causes of aplastic anaemia

Answer 2

Idiopathic
Congenital
Drugs
Toxins - benzene
Infections
Radiation

Question 3

Congenital causes aplastic anaemia

Answer 3

Fanconi syndrome, dyskeratosis congenita

Question 4

Drugs casuing aplastic aaemia

Answer 4

Cytotoxics
Chloramphenicol
Sulphonamides
Phenytoid
Gold

Question 5

Viral causes aplastic anaemia

Answer 5

Parvovirus, hepatits

Question 6

Clinical features of alastic anaemia

Answer 6

Normocytic anaeia
Leukopenia (sparing of lymphocutes)
TP
Can be presenting feature of ALymphoblastic or MLeukaemia
May go on to PNH or myelodysplasia

Question 7

Management of aplastic anaemia supportive

Answer 7

Blood products
Prevention and treatment of infection

Question 8

Treatment aplastic anaemia

Answer 8

Anti-thymocyte globulin - ATG
Anti-lymphocyte globlin - ALG
+ steroids (prevent allergy)
Immunosupression eg ciclosporin
Aloogeneic stem cell transplants

Question 9

What can ATG and ALG cause

Answer 9

Serum sickness syndorme