April 3 Flashcards Preview

Designated study period: daily cards > April 3 > Flashcards

Flashcards in April 3 Deck (13):
1

Thoracic outlet syndrome

Compression by rib/clavicle, pectoralis muscle, or ant and middle sclaenes.

Compression of lower trunk can result in numbness, tingling, weakness
Compression of subclavian vein can cause swelling
Compression of subclavian artery can cause exertional arm pain

Associated with repetitive overhead arm use

2

Vascular supply to femoral neck

Medial circumflex

3

Bisphosphanate MOA

Inhibits mature osteoclast-mediated bone resorption. Structure similar to pyrophosphate. Attach to hydroxyapatite binding sites.

4

Colchicine ADRs

Nausea, abdominal pain, and diarrhea due to disruption of MT formaiton in gastric mucosa

5

Glucocorticoid myopathy

Painless weakness and atrophy

6

Hypothyroid myopathy

Muscle pain, cramps, weakness of proximal muscles, delayed DTRs, myoedema

7

Blood supply to thyroid

Superior thyroid artery: branch of external carotid. Runs with ext branch of sup laryngeal nerve which innervates cricothyroid. Can be damaged during thryoid surgery

Inf thyroid artery branch of thyrocervical trunk

8

Thiamine

Cofactor for pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, transketolase

9

Hashimoto's thyroiditis pathology

Lymphocytic infiltration with germinal centers

10

Glucagonoma presentation

Diabetes
GI symptoms
Necrolytic migratory erythema

11

NIacin ADR

Flushing, hyperglycemia, hepatotoxicity, elevated uric acid which can precipitate gout

12

Calcium sensing receptor

GPCR that regulates PTH in reponse to circulating Ca++

13

SGLT2 inhibitors

end in - gliflozin. Increase urine glucose loss. Side effects are UTIs, hypotension. Contraindicated in renal failure