March 31 - Micro Flashcards Preview

Designated study period: daily cards > March 31 - Micro > Flashcards

Flashcards in March 31 - Micro Deck (14):
1

Protease inhibitors: names, MOA, and ADRs

NAmes: all end in "-navir"
MOA: Prevent cleavage of gag and pol into functional units, preventing viral particle maturation
ADRs: increased lipids and hyperglycmeia, fat redistribution

2

NRTIs: names, ADRs

Names: zidovudine, lamivudine, tenofovir, didanosine
ADRs: mitochondrial toxicity (inhibit DNA pol gamma); peripheral neuroatphy; bone marrow suppression; myopathy; pancreatitis; lactic acidosis

3

NNRTIs: names, MOA, ADRs

Nevirapine, efavirenz, delavirdine
MOA: unlike NRTIs don't require activation by phosphorylation. Not effective against HIV-2
ADRs: skin rash, metabolied by CYP

4

Echinococcus granulosus

Tape worm that causes hyatid cysts. Associated with sheep and dog exposure. Often involves liver, causing encapsulated calcified cysts. Risk of anaphylaxis when treated surgically

5

Helminth treatment

Intestinal roundworms: bendazoles or pyrantel pamoate
Flukes and tapeworms: praziquantel expect for echinococcus

6

Typhoid fever presentation

Week 1: rising fever, bacteremia, bradycardia
Week 2: abdominal pain, rose spots on trunk and abdomen
Week 3: HSM, intestinal bleeding and perforation due to ulceration of Peyer's patches

7

Syphilis lesions in different stages

Primary: chancre (painless ulcer)
Secondary: chondyloma lata (large grey warts in genital region)
Tertiary: gummas (painless gray granulomatous lesions that can be cutaneous or visceral)

8

Flucytosine

Inhibits fungal DNA replication and RNA synthesis

9

Integrase inhibitors: names, ADR

Names: end in "-gravir"
ADR: myopathy

10

Enfuvirtide

fusion inhibitor. Binds envelope protein gp41 inhibiting HIV fusion with target cell membrane

11

Maraviroc

CCR5 antagonist. Inhibits HIV entry by blocking interaction betwee gp120 and CCR5

12

drugs with anaerobic coverate

pip-taz, metronidazole, carbapenems, clindamycin

13

Vitamine to supplement in measles

vitamin A

14

LPS

Toxin released when gram neg cell wall destroyed. Consists of O antigen (used for typing), core polysaccharide, and lipid A (toxic component)

Lipid A activates macrophages and granulocytes leading to synthesis of inflammatory mediators and endogenous pyrogens