Ascending pathways of spinal cord Flashcards by Bryce Harmon

3 diff categories of ascendin info carried by spinal cord

discriminatory - determines type/location/intensity of stimulus
reflexive - activates responses to create behavioral state change with appropriate stereotyped motor responses
Postural - informs or joint, tendon, and muscle position at unconscious level

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discriminatory

•Dorsal columns/medial lemniscus (DCML)
–Fasciculus gracilis
–Fasciculus cuneatus
•Anterolateral system
–Neospinothalamic

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reflexive

•Anterolateral system
–Paleospinothalamic
–[Spinoreticular]
–[Spinomesencephalic

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postural

•Spinocerebellartracts
–Cuneocerebellar
–[Rostral spinocerebellar]
–Dorsal spinocerebellar
–Ventral spinocerebellar

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faster, wider axons

travel to white matter in posterior funuliculi, mechanoreception and tactile, type I and II

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slower, thin axon

travel to lamina I to VI in dorsal horn, nociceptive (nociceptors, themoreceptors, mechanoreceptors, and visceral afferents, Adelta and C

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discriminatory pathway are how many neurons long

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postural pathways are how many neurons long

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discriminatory or non-discriminatory decussates?

discriminatory (pinpointing goes to other side, non-pinpointing does not)

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Dorsal Columns also called the

posterior columns
medial lemniscus (when in medulla)

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dorsal columns type of info

tactile discrimination and conscious prorioception

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dorsal columns point of origin

meissners corpuscle
merkesl disks
pacinian corpuscles
ruffinis ending in skin muscle spindles
Golgi tendon organs in muscles joints and tendons

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dorsal columns cell bodies

dorsal root ganglion

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dorsal columns first synapse

nucleus cuneatus or gracilis in caudal medulla

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dorsal columns enters spinal cord

medial aspect of dorsal horn, fasciculus cuneatus or gracilis

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dorsal columns decussates

internal arcuate fibers ventral to cuneatus and gracilis (becomes medial lemniscus)

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dorsal columns second synapse

ventral posteriolateral nucleus (VPL) or thalamus

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dorsal columns final destination

primary somatosensory cortex (via internal capsule and corona radiata

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where is posterior intermediate sulcus located

thoracic and higher

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gracilis is for

lower part of body, lumbar and sacral, nuclei separated by posteiro intermediate septum

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cuneatus is for

upper part of body, thoracic and cervical

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cuneatus in lumbar

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how is information organized in posterior columns

lumbar has no posterior intermediate sulcus, info is organized from medial to lateral with medial being lower in body

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intermediate sulcus does what

divides gracilis and cuneatus

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in medulla fasciculi change to

nuclei

tactile nociceptive and conscious proprioceptive infor are represented where

primary somatosensory cortex

dorsal columns internal arcuate fasciculus

arching fibers | settle at the medial lemniscus

Anterolateral system neospinothalamic is called the

neospinothalamic tract

Anterolateral system type

pain, temp and poorly localized touch

Anterolateral system neospinothalamic point of origin and receptors

free nerve endings (TRP Vchannels) in skin viscera and muscles

Anterolateral system neospinothalamic primary cells bodies

dorsal root ganglion

Anterolateral system neospinothalamic first synapse

Lamina I-VI

Anterolateral system neospinothalamic enters spinal cord and travels

dorsal horn (Lissauer’s Fassciculusto ascend at least 1 segment), after 1stsynapse, travels through anterior white commissure, ascends through anterolateral spinothalamictract

anterolateral system neospinothalamic decussates

spinal cord after first synapse

anterolateral system neospinothalamic second synapse

ventral posteriolateral nucleus (VPL) of thalamus

anterolateral system neospinothalamicfinal desination

primary somatosensory cortex (via internal capsule and corona radiate)

anterolaterl system neospinothalamic organized in spinothalmic tract

CTLS from mdial to posterior

anterolateral system neospinothalamic tidbits

2nd order neuron is highly myelinated | in midbrain anterolateral and medial lemniscus kindof merge so you get pain and tactile in same place

Anterolateral system Paleospinothalamic tract type of info

poorly localized pain, fibromyalgia

Anterolateral system Paleospinothalamic tract point of origin and receptors

Free nerve endings (TRP channels) in skin, viscera, muscles

Anterolateral system Paleospinothalamic tract primary cell bodies

dorsal root ganglion

Anterolateral system Paleospinothalamic tract first synapse

Lamina I-VI

Anterolateral system Paleospinothalamic tract enters spinal cord and travels

dorsal horn (Lissauer’s Fassciculusto ascend at least 1 segment), after 1stsynapse, travels bilaterally, ascends through anterolateral spinothalamictract

Anterolateral system Paleospinothalamic tract decusstes

spinal cord after 1st synapse

Anterolateral system Paleospinothalamic tract second synapse

intralaminar nuclei of thalamus

Anterolateral system Paleospinothalamic tract final destination

bilateral cortex, poorly localized (includes cingulate gyrus and insula (both in limbic lobe, have bad feeling with fibromyalgia))

syrinx in spinal cord

get syringomyelia, a problem with horns which usually aren't affected bc ther are interior, but fluid filled sac is pressing on them

4 tracts that make up prorioception

* Dorsal spinocerebellar - lower fine component of prorpioception * Ventral spinocerebellar - lower whole limby prioprioception * Rostral spinocerebellar(?) - upper limb prioprioception (don't worry about) * Cuneocerebellar - upper limb fine prioprioception

Dorsal Spinocerebellar and cunocerebellar type of info

unconscious proprioception

Dorsal Spinocerebellar and cunocerebellar point of origin and receptors

muscle spindles, Golgi tendon in muscle joint and tendons

Dorsal Spinocerebellar and cunocerebellar cell bodies

DRG

Dorsal Spinocerebellar and cunocerebellar 1st synapse

Clarke’s Nucleus (aka nucleus dorsalis) of thoracic cord if dorsal spinocerebellar. Accessory cuneatenucleus in caudal medullaif cuneocerebellar

Dorsal Spinocerebellar and cunocerebellar enters spinal cord and travels

posterior funiculi (thickens with dorsal columns)

Dorsal Spinocerebellar and cunocerebellar decussates

none

Dorsal Spinocerebellar and cunocerebellar second synapse

vermis/paravermis of the cerebellum via inferior cerebellar peduncle

dorsal spinocerebellar and cuneocerebellar final destination

deep cerebellar nuclei (via purkinje cells)

Dorsal spinocerebellar overview

hitchhikes on fasciculus gracilis until l3 then it is visible as dorsal spinocerebellar tract not visible until l3

cuneocerebellar

hitchhikes on fasciculus cuneatus

clarkes nucleus

DORSAL SPINOCEREBELLAR •When below C8, unconscious proprioceptiveinfo hitchhikes on posterior column. –Synapses in Lamina VII –Visible L3 to C8 •CLARKE’S COLUMN/CLARKE’S NUCLEUS/NUCLEUS DORSALIS

cuneocerebellar above C8

•When above C8, synapses in accessory/external/lateral cuneate nucleus –Caudal Medulla

which sense is ipsilaterla, contralateral and bilateral

ipsi - proprioception contra-discriminatory bilat-reflexes

Dorsal Spinocerebellar and cunocerebellar in cerebellum

intracerebellar pathway enter through peduncle and are changed to mossy fibers mossy fibers synapes on granule cells creating second synapse in the system granule cell axons go to superior surface and bifurcate and then are called parallel fibers which then synapse on purkinje cells purkinje cells take axon signal to dcn (deep cerebellar nuclei) last one is 5th order neuron

Ventral spinocerebellar type o info

unconscious proprioception

Ventral spinocerebellar point of origin and receptors involved

muscle spindle, Golgi tendon organ in muscle joint and tendon

Ventral spinocerebellar cell bodies

drg

Ventral spinocerebellar first synapse

lamina VII then travels to posterior funiculi

Ventral spinocerebellar decussates

immediately in spinal cord

Ventral spinocerebellar second synapse

vermis/paravermisof the cerebellum via superiorcerebellar peduncle. Will then decussate again!

Ventral spinocerebellar final destination

deep cerebellar nuclei (via purkinje cells)

Ventral spinocerebellar hitchkies

hitchhikes on fasciculus gracilis until clarkes nucleus appears (synapes right next to it in lamina VII)