Asfarviridae Flashcards
(17 cards)
T/F. Asfarviridae viruses are not enveloped.
False. They are enveloped virions with a nucleocapsid core surrounded by an internal lipid layer and an icosahedral capsid.
Describe the genome of Asfarviridae.
single linear dsDNA
Where does replication of Asfarviridae viruses occur?
cytoplasm
What is the only member of Asfarviridae?
African Swine Fever
T/F. ASF is one of many DNA arboviruses.
False. It’s the only known DNA arbovirus!
What species are ASF reservoirs that exhibit inapparent infections?
Warthog, bush pig, Giant forest hog
Where is ASF endemic?
Sardinia and sub-Saharan Africa
T/F. ASF multiplies in vectors.
True. Soft Tick.
What is Hemadsorption?
- Means the virus does not hemagglutinate
- RBCs adhere to the surface of MQ cells infected with ASF d/t virus-specific protein on membrane of infected cells in late infection
- Rosette formation
T/F. Ticks can pass ASF to other ticks.
True
Which reservoir age group exhibits viremia with ASF: young pigs, old pigs?
Young pigs after primary infection. Can also infect the feeding ticks
T/F. ALL bodily fluids and tissue contain the infective virus in the Domestic Cycle of ASF.
True
How does ASF cause apoptosis?
-p54 encoded by virus–> release cytokines and apoptotic mediators –> lymphocyte and MQ apoptosis
What will the skin of a pig acutely infected with ASF look like?
cyanotic skin blotching
erythema
What is a pathognomonic necropsy finding associated with ASF?
blackberry jam spleen
T/F. Vaccines are effective in prevention of ASF.
False. NO vaccine
T/F. ASF is reportable.
True
