Aspirin Flashcards
(18 cards)
aspirin classification
NSAID
therapeutic activity of aspirin
Anti-pyretic
Anti-platelet/thrombotic
Anti-inflammatory
Analgesic for mild to moderate pain
presentation of aspirin
Tablet, dispersible
aspirin is not dissolvable in the mouth, what issues can it cause if it direct contact with mouth tissues
sloughing and ulceration of tissues
mechanism of action of aspirin
COX inhibition which inhibits the production of prostaglandins
does aspirin have a reversible affect on platelets
no irreversible
where is aspirin absorbed
stomach and small intestine
contra-indications for aspirin 5
pregnancy, asthmatics, anti-coagulated, methotrexate
children <16yrs
why should aspirin be avoided in children <16yrs
risk of Reye’s syndrome which results in liver damage
side effects of aspirin
bleeding tendency
what is used to remember aspirin interactions? what affect does aspirin have on them?
4 ANTS - enhances the effect of these
what are the 4 ANTS - interactions of aspirin
Anticoagulants - warfarin
Antihypertensives - ACE inhibitors, beta blockers
Antidepressants - SSRIs
Antiepileptics
NSAIDs
Thrombocytes - drugs that affect it
Steroids - increase risk of GI events
what are thrombocytes
platelets
aspirin dose
mg
hrly
max
300-900
4-6hrly
4g in 24hrs
ibuprofen dose
mg
daily
hrly
max
400mg
3 times daily
8hrly
2.4g max in 24hrs
diclofenac
mg
daily
hrly
max
50mg
3 times daily
8hrly
150mg max in 24hrs
what amount is an overdose of aspirin
10-30g
how is aspirin overdose managed?
requires hospitalisation to monitor pH, electrolytes
