paracetamol Flashcards
(19 cards)
what is another name for paracetamol
acetaminophen
what drug classification is paracetamol in
non-opioid analgesic and antipyretic agent
therapeutic activity of paracetamol 3
Analgesic for mild to moderate pain
Antipyretic
Anti-inflammatory
paracetamol mechanism of action
○ Unclear
Inhibitor of some peroxygenase -> inhibits cox-1/2 activity
paracetamol half life
2-4hrs
what is N-acetyl-p-benzoquinone imine
a toxic metabolite of paracetamol
indications for paracetamol 3
1st line analgesic for mild to moderate dental pain
Inflammatory conditions
Cant use NSAIDs
contraindications for paracetamol
few
side effects of paracetamol
Skin reactions, blood dyscrasias, hepatoxicity
Liver failure
fewer than NSAIDs
interactions of paracetamol
Cytochrome P450 inducing drugs - SCRAPP
paracetamol interacts with cytochrome P450 inducing drugs name these 7
St john’s wart
Carbamazepine
Rifampicin
Alcohol
Phenobarbitol
Phenytoin
Primidone
paracetamol dose:
mg/kg
hrs
max
10-15mg/kg
4-6hrs
4g in 24hrs
what can 8g of paracetamol cause
acute liver damage
what is the fatal dose of paracetamol
25g
what is an overdose of paracetamol
> 150mg/kg
how is paracetamol overdose treated?
Treatment hospital
activated charcoal
acetylcysteine IV
route of administration of paracetamol 3
Oral, IV and rectal suppository
what affects dose?
Renal insufficiency - increase the minimal dosing frequency - 6hrs instead of 4hrs
special considerations for paracetamol
Liver disease, alcohol, malnutrition, dehydration
