clindamycin

Question 1

clindamycin drug class

Answer 1

lincosamide

Question 2

clindamycin mechanism of action

Answer 2

Inhibits protein synthesis by binding to 50S ribosomal subunit

Bacteriostatic but at high concentrations we use is bactericidal

Question 3

clindamycin half life

Answer 3

3hrs

Question 4

indications for clindamycin

Answer 4

Second line for oro-facial infections if cant use penicillin/metronidazole

Question 5

contraindications for clindamycin

Answer 5

allergy

Question 6

main unwanted side effect from clindamycin

Answer 6

Pseudomembranous colitis/ antibiotic associated colitis - potentially fatal, advise pt to stop taking immediately if have diarrhoea

Question 7

clindamycin interactions 3

Answer 7

Erythromycin - antagonism

Anti-diarrhoeal drugs

Non-depolarising neuromuscular blocking agents

Question 8

clindamycin dose
mg
hrly
days
route of administration
loading dose

Answer 8

150-300mg
6hrly
3-5days
oral
no

Question 9

clindamycin clearance where

Answer 9

hepatic - liver