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Paramedic Drugs Set 4 - Hypotension / Bradycardia > Atropine > Flashcards

Flashcards in Atropine Deck (7)
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1

Classification

Parasympathetic (anticholinergic, antimuscarinic)

2

Mechanism of Action

  • Competes reversibly with acetylcholine at the site of the muscarinic receptor.
  • Receptors affected in order from most to least sensitive, salivary, bronchia, sweat glands, eye, heart, and GI tract
  • Increases heart rate

3

Indications

  • Symptomatic bradycardia, asystole or PEA
  • Nerve agent exposure
  • Organophosphate poisoning

4

Contraindications

  • Known sensitivity to atropine, belladonna alkaloids, or sulfites

5

Adverse Effects

  • Decreases secretions result in dry mouth and hot skin temperature, intense facial flushing, blurred vision, or dilation of pupils with subsequent photophobia. 
  • May cause paradoxical bradycardia if dose is too low or pushed too slowly. 

6

Administration

  • Symptomatic Bradycardia
    • Adult: 0.5 mg IV/IO every 3-5 minutes to a max of 3 mg.
    • Pediatrics: .02 mg/kg (min .1 mg/dose, max .5 mg/dose) IV/IO total dose of 1 mg.
  • Asystole/PEA
    • 1 mg IV/IO every 3-5 minutes, max dose 3 mg. May be administered ETT at 2-2.5 mg diluted in 5-10 ml of water or NS.
  • Nerve Agent or Organophosphate Poisoning
    • ​​​2-4 mg IV/IO/IM, repeat if needed eery 20-30 minutes until symptoms resolve. In severe cases doses may be as large as 2-6 mg IV. 

7

Special Considerations

  • Half Life 2.5 hours
  • Closed angle glaucoma
  • May not be effective for high-degree AV blocks.