Dopamine (Intropin) Flashcards Preview

Paramedic Drugs Set 4 - Hypotension / Bradycardia > Dopamine (Intropin) > Flashcards

Flashcards in Dopamine (Intropin) Deck (7)
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1

Classification

Sympathomimetic, adrenergic agonist, inotropic, vasopressor

2

Mechanism of Action

  • Stimulates alpha & beta adrenergic receptors
  • At moderate doses (2-10 mcg/kg/min), dopamine stimulates beta 1 receptors, increaseing inotropy and cardiac output while maintaining dopaminergic-induced vasodilatory effects.
  • At high doses (10-20 mcg/kg/min), alpha adrenergic agonism predominates causing increased peripheral vascular resistance and vasoconstriction. 

3

Indications

  • Hypotension & decreased cardiac output associated with cardiogenic shock & septic shock
  • Hypotension after ROSC following cardiac arrest
  • Symptomatic bradycardia unresponsive to atropine

4

Contraindications

  • Hypovolemic shock (correct with volume fluid replacement before giving dopamine)
  • Pheochromocytoma
  • VF, VT, or other ventricular arrythmias
  • Known sensitivity (including sulfites)

5

Adverse Effects

  • Tachycardia, arrythmias
  • Skin & soft tissue necrosis
  • Severe hypertension from excessive vasoconstriction
  • Angina
  • Dyspnea, headache, nausea, vomiting

6

Administration

  • Adult: 2-20 mcg/kg/min IV/IO infussion
    • Cardiac dose is usually 5-10 mcg/kg/min
    • Vasopressor dose is usually 10-20 mcg/kg/min
    • Little benefit with doses over 20 mcg/kg/min
  • Pediatrics: Same as adult dosing

7

Special Considerations

  • Half life is 2 minutes.