Autoimmune disease

Question 1

Autoimmune hemolytic anemia

Answer 1

1. Rh blood group antigen, I antigen

2. Destruction of RBC by complement and phagocytes

Question 2

Autoimmune thrombocytopenia purpura

Answer 2

1. Platelet integrin gpIIb:IIIa

2. Abnormal bleeding

Question 3

Goodpasture’s syndrome

Answer 3

1. Non-collagenous domain of basement membrane collage type 4
2. Glomerulonephritis, pulmonary hemorrhage

Question 4

Pemphigus vulgaris

Answer 4

1. Epidermal cadherin

2. Skin blistering

Question 5

Pemphigus foliaceus

Answer 5

1. Desmoglein

2. Mild skin blistering

Question 6

Acute rheumatic fever

Answer 6

1. streptococcal cell wall antigen, cross react with cardiac m.
2. Arthritis, myocarditis, scarring of heart valves

Question 7

Graves’ disease

Answer 7

1. TSH hormone receptor

2. Hyperthyroidism

Question 8

Myasthenia gravis

Answer 8

1. ACh receptor

2. Progressive weakness

Question 9

Type 2 diabetes

Answer 9

1. Insulin receptor(antagonist)

2. Hyperglycemia, ketoacidosis

Question 10

Hypoglycemia

Answer 10

1. Insulin receptor(agonist)

2. Hypoglycemia

Question 11

Pemphigus foliaceus

Answer 11

1. Desmoglein

2. Mild skin blistering