Autoimmune disorders Flashcards
(20 cards)
Church strauss charact
small vessel vasculitis
asthma
allergic rhinitis
prominent esonophillia
positive MPO ab
wegenener charac
triad of necrotising granulamatous inflammation
GN
small vessel facilities
Conditions RF positive in
Sjogren’ssyndrome, MCTD, PM/DM, Scleroderma, AAV, Polyarteritisnodosa, Primary Biliary Cirrhosis, sarcoidosis
SBE, mTB, leprosy, syphilis, HepC & B (cryoglobulins), viral & parasitic infections
Non radiographic diagnosis of axial spondyloarthtiritis
Inflammatory back pain enthesisitis dactylitis IBD psoarisis
Criteria for inflammatory Back pain
age less than 40 insidious onset better with exercise not impvoed with resting worse at night
x ray findings psoriatic arthritits
joint erosions
new joint proliferation
osteolysis
ankylosis- spur formation
most specific feature of psoaritic arthritis
enthesitis
Investigations SLE
ANA dsDNA c3,c4 anti smooth muscle ab biopsy proven lupus nephritis Antiphosholipid syndrome ab
Sjogren investigations
ANA ENA RF Cryoglobins Biopsy - lower lip or salivary gland
MRI- parenchymal heterogeneity
Sjogren- Schimier test- see 5 minutes if less than 5mm diagnostic (how dry the eyes are)
Scleroderma
ANA
Antitopoisomerase (Anti SCl 70)- ILD association + diffuse skin disease
Anticentromere ab- CREST syndrome- also associated PBC + Sjogren
Anti RNA polymerase 3- rapid diffuse skin involvement. - high risk of renal crisis.
Other tests: ECHo pulm htn, RFT- restrictive pattern
CT chest- ILD
when suspect igG4 disease
no etiology for pancreatitis, bilateral lacrimal gland enlargement
retroperitoneal fibrosis.
Diagnosis- biopsy
Mx steroids if not then rituximab
antisynthetase syndrome
Anti Jo 1- mechanical hand, ILD, raynauds, fever,
Necrotising myopathy - investigation
Anti- SRP
anti hmg cr
(Associated with use of statins and cancer-paraneoplastic)
Clinically amyopathic dermatomyositis
Anti-MDA-5/Anti-CADM-140 • Rapidly progressive ILD
Cancer asscociated dermatomyositis
Anti-p155/140
inclusion body myositis
Anti-CN-1A/Mup44
From biopsy how to differentiate myositis from dermatomyositis
in myositis- intrafascicular
in dermatomyositis- perifascicular
Large vessel vasculitis causes
Takayasu (mainly affect aorta)
Giant cell arteritis
medium vessel vasculitis causes
polyarteritis nodusa
Small vessel vasculitis
-ANCA associated
Eosinophilic granulomatosis with polyangiitis(Churg-Strauss)
• Granulomatosis with polyangiitis(Wegener’s) - PR3 ANCA
• Microscopic polyangiitis MPO ANCA
• Henoch-Schonlein Purpura (IgA vasculitis)
• Cryoglobulinaemic vasculitis • Connective tissue disease related
-variable- behcet
