SLE

Question 1

genetic factors cause of SLE

Answer 1

Deficiency complements- c1q, c4a, B

TREX1 gene mutations

Question 2

drug induced lupus examples

Answer 2

procainamide

hydralazine

Question 3

most common symptoms at onset

Answer 3

arthralgia

Question 4

mucotanoues symptoms chornic lupus

Answer 4

Discoid lupus

Question 5

rhupus

Answer 5

Ra and SLe combination- anticcp present- more erosive disease

Question 6

jacouds arthropathy

Answer 6

2nd to 5th fingers ulnar deviation with MCP joint subluxation

Question 7

neuropsychiatric symptoms SLE

Answer 7

Cognitive dysfunction- most common
headache
mood disorder

Question 8

Renal Lupus cassification

Answer 8

Class I Minimal mesangial (IF change only)
Class II Mesangial proliferative
Class III Focal (< 50% of glomeruli) A: active, A/C: active + chronic, C: chronic lesions
Class IV Diffuse (> 50% of glomeruli) A, A/C, C
Class V Membranous
Class VI Advanced sclerosing

Question 9

requirements SLE diagnosis

Answer 9

≥ 4 criteria - at least 1 clinical and 1 immunologic OR •

biopsy-proven lupus nephritis with positive ANA or anti-dsDNA

Question 10

ANA positive in

Answer 10

Scleroderma
MCTD
PM/DM
Sjogren
Hashimoto
Graves
Hep C

Question 11

Hydrochloroquine benefits in SLE

Answer 11

decreased flares
decreased orga damage
improve surival

Question 12

treatment Lupus neph

Answer 12

class 1 and 2 no immunosuppression
class 3 and 4- induction, maintenance, serological monitoring
class 5 treat as class 3 and 4

Question 13

belimumab

Answer 13

Mab against MAB (B cell activating factor)

Question 14

anti phospho lipids abs positive mamanegent in pregnancy

Answer 14

Asymptomatic- aspirin
prior obstetric- give heparin + aspirin
Prior thrombosis- clexane thrapeutic