Autoimmune Hemolytic Anemias Flashcards
Immune hemolytic anemia is defined as
shortened RBC survival mediated through humoral antibody production
Which of the following characterizes an alloimmune response in immune hemolytic anemia?
patient produces anti-k to transfused red blood cells
Which of the following signifies intravascular hemolysis in autoimmune hemolytic anemia (AIHA)?
hemoglobinuria
All of the following are characteristics of benign cold autoagglutinins except:
Antibodies have a titer greater than 64 and 4 degrees C
When might a benign cold autoagglutinin cause interference in antibody screening procedures?
when polyspecific AHG reagents are used in the test procedure
Which cells contain the most i antigen?
cord blood
All of the following are clinical manifestations of cold hemagglutinin disease (CHD) except:
hepatosplenomegaly
How can persons with cold hemagglutinin disease (CHD) avoid hemolytic episodes?
move to a warm climate
The onset of warm autoimmune hemolytic anemia (AIHA) may be precipitated by:
pregnancy
bacterial infection
trauma
Which of the following can be found in warm autoimmune hemolytic anemia in the presence of a hyperplastic marrow?
reticulocytosis
Which of the following forward-typing reagents may generate false positive results in a patient with a warm-reacting autoantibody?
anti-D
In the case of an AB-positive individual, what test must be performed to ensure that a warm-reacting autoantibody is not causing false positive reactions?
Rh control
Most cases of warm autoimmune hemolytic anemia will be DAT positive with which of the following?
both anti-IgG and C3d
What is one indication a positive DAT might be due to alloantibody coating donor red cells
microscopic mixed-field appearance
What treatment for warm autoimmune hemolytic anemia aids in the reduction of antibody and removes a potent site of red blood cell damage and destruction?
splenectomy
