Autoimmunity

Question 1

Type 2 Autoimmune Conditions are mediated by

Answer 1

IgG specific for determinants of cell surface structures/ECM

Question 2

Autoimmune (Idiopathic) Thrombocytopenic Purpura

Answer 2

IgG-mediated inhibition of an enzyme responsible for cleavage of vWF

Question 3

Autoimmune diseases that involve IgE

Answer 3

None

Question 4

Autoimmune Hemolytic Anemia is caused by

Answer 4

IgG and Igm specific for surface antigens of RBC’s

Question 5

Bence-Jones Proteins

Answer 5

Cryoglobulins composed only of light chains

Question 6

Cause of Grave’s Disease

Answer 6

IgG binds to TSH receptor –> Overproduction of thyroid hormone

Question 7

Cellular mediator of Multiple Sclerosis

Answer 7

Th1 CD4 Effector Cells –> Activate macrophages

Question 8

Cryoglobulins

Answer 8

Ig’s that become insoluble at reduced temperature

Question 9

Cyroglobulins are most often produced by patients that have

Answer 9

B cell proliferative disorder (multiple myeloma, etc)

Question 10

Damage from Goodpasture’s Syndrome

Answer 10

Kidney damage

Question 11

Dx of Autoimmiune Thrombocytopenic Purpura

Answer 11

Microangioplastic Hemolytic Anemia

Question 12

Goodpasture’s Syndrome

Answer 12

IgG specific for Type-IV collagen (basement membranes)

Question 13

Guillan Barre Syndrome

Answer 13

Type 2 AI disease mediated by IgG specific for gangliosides –> Demyelination

Question 14

IgG binds to TSH receptor –> Overproduction of thyroid hormone

Answer 14

Cause of Grave’s Disease

Question 15

IgG specific for ACh receptors on muscle cells

Answer 15

Myasthenia Gravis

Question 16

IgG specific for Desmoglein 1 and 3 –> Loss of cohesion in keratinocytes in epidermis

Answer 16

Pemphigus Vulgaris

Question 17

IgG specific for Type-IV collagen (basement membranes)

Answer 17

Goodpasture’s Syndrome

Question 18

IgG-mediated inhibition of an enzyme responsible for cleavage of vWF

Answer 18

Autoimmune (Idiopathic) Thrombocytopenic Purpura

Question 19

Immune-Complex Diseases

Answer 19

(1) Subacute Bacterial Endocarditis; (2) Mixed Essential Cryoglobulinemia; (3) Systemic Lupus Erythematosus

Question 20

Inflammatory destruction of vascular endothelial cells of arterioles and SM cells; replacement with collagen and fibrous material

Answer 20

Scleroderma

Question 21

Meltzer’s Triad

Answer 21

Purpura, Athralgia, Myalgia; Mixed Essential Cryoglobulinemia

Question 22

Mixed Essential Cryoglobulinemia is a common sequelae to

Answer 22

Infection with Hepatitis C

Question 23

Myasthenia Gravis

Answer 23

IgG specific for ACh receptors on muscle cells

Question 24

Organ effected by Addison’s Disease

Answer 24

Adrenal Gland

Question 25

Pemphigus Vulgaris

Answer 25

IgG specific for Desmoglein 1 and 3 --> Loss of cohesion in keratinocytes in epidermis

Question 26

Rhematoid Factor

Answer 26

IgG, IgM, and IgA specific for the Fc region of antibody molecules

Question 27

Scleroderma

Answer 27

Inflammatory destruction of vascular endothelial cells of arterioles and SM cells; replacement with collagen and fibrous material

Question 28

Symptoms of Mixed Essential Cryoglobulinemia

Answer 28

Meltzer's Triad: Purpura, Athralgia, Myalgia

Question 29

Symptoms of Pemphigus Vulgaris

Answer 29

Painful chronic blisterin of skin

Question 30

Treatment of Autoimmune Hemolytic Anemia

Answer 30

Corticosteroids

Question 31

Type 2 AI disease mediated by anti-neutrophil cytoplasmic Ab's (ANCAs)

Answer 31

Wegener's Granulomatosis

Question 32

Type 2 AI disease mediated by IgG specific for gangliosides --> Demyelination

Answer 32

Guillan Barre Syndrome

Question 33

Type 3 Autoimmune Conditions are mediated by

Answer 33

IgG, immune complex disease

Question 34

Type sof Ab's in Scleroderma

Answer 34

Anti-nuclear, Anti-topo, Anti-centromere

Question 35

Wegener's Granulomatosis

Answer 35

Type 2 AI disease mediated by anti-neutrophil cytoplasmic Ab's (ANCAs)

Question 36

What initiates Subacute Bacterial Endocarditis

Answer 36

IgG that binds microorganisms that have colonized damaged heart valves

Question 37

What mediates inflammation in Subacute Bacterial Endocarditis

Answer 37

Phagocytes that recognize opsonized bacteria; Anaphylotoxins