Hypersensitivities Flashcards
(24 cards)
Which is immediate type hypersensitivity
Type 1
Allergens for immediate-type HS are often
proteases (think parasites)
Cellular mediator of Tuberculin reaction
Th1 CD4 T cells
Effect of IL-4 and IL-13 from Mast Cells
Stimulate and amplify TH2-cell response
Effect of Leukotrienes from Mast Cells
SM contraction, Vascular permeability, Mucus secretion
Effect of Mast Cells on Airways
Decreased diameter, increased mucus secretion
Effect of Mast Cells on GI tract
Increased fluid secretion and peristalsis
Farmer’s Lung
Inhaling mold spores and other allergens from hay –> Chronic deposition of immune complexes
Immune reactant for Type 2 HS?
IgG
Immune reactant for Type 3 HS?
IgG
Major cytokine of Mast Cells
TNF-alpha
Mast Cell enzymes
Tryptase, Chymase, Cathepsin G, Carboxypeptidase
Mast Cell toxic mediators
Histamine, Heparin
Most Common Type 3 Hypersensitivities
Farmer’s Lung, Bird-Fancier Disease
Time frame of Type 2 HS?
4-12 hours
Time frame of Type 4 HS?
24-72 hours
Type 1 HS allergens must be __ bc they only induce ___ responses
proteins, T cell
What initiates type 1 HS?
Mast cell degranulation (IgE crosslinking)
What initiates type 2 HS?
Allergen-specific IgG Ab’s (mediated by complement, phagocytes, and NK cells)
What mediates type 2 HS after initiated?
Complement cascade, phagocytes, and NK cells
What mediates Type 4 HS?
T cells (either 4 or 8)
Which is delayed-type hypersensitivity
Type 4
Which is immune complex type hypersensitivity
Type 3
Which is modified self type hypersensitivity
Type 2
