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Immunology 2 > Week 2 (minus Vaccinations) > Flashcards

Week 2 (minus Vaccinations) Flashcards

(77 cards)

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1
Q

Principle tissues affected in GvH Disease

A

Skin, Intestines, Liver (inflammation of bile duct)

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2
Q

3 most often used immunosuppressives for transplant

A

Corticosteroids, Cytotoxic, Microbial Products

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3
Q

3 Symptoms of GvH Disease:

A

(1) Maculopapular Skin Rash; (2) High Serum Levels of Bilirubin; (3) Diarrhea

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4
Q

Major cause of morbidity and mortality after bone marrow transplantation

A

Graft vs Host disease

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5
Q

Most common cause of hyperacute rejection

A

Mismatched blood types

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6
Q

Most important action of corticosteroids

A

Inhibit NFKB

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7
Q

Most important action of Cytotoxic drugs in immunosuppression

A

Kill proliferating lymphocytes by interfering with DNA replicaiton

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8
Q

Most important action of microbial products in transplant

A

Inhibit signaling pathways for T cell activation

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9
Q

Only genetic factor that must be considered before liver transplantation

A

ABO Blood groups

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10
Q

T/F: The placenta expresses MHC

A

False, fetal tissue

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11
Q

The alloreactions that occur following blood transfusion to not involve

A

T cells

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12
Q

Timeline of Acute Rejection

A

11-15 days after transplantation (absence of anti-inflammatory)

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13
Q

Timeline of rejection mediated solely by minor histocompatibility antigens

A

30-60 days

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14
Q

Timeline of Second-Set Acute Rejection

A

4-7 days

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15
Q

What mediates Acute Rejection

A

CTL’s

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16
Q

Why is the cornea immunologically privileged

A

Not vascularized

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17
Q

Type 2 Autoimmune Conditions are mediated by

A

IgG specific for determinants of cell surface structures/ECM

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18
Q

Autoimmune (Idiopathic) Thrombocytopenic Purpura

A

IgG-mediated inhibition of an enzyme responsible for cleavage of vWF

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19
Q

Autoimmune diseases that involve IgE

A

None

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20
Q

Autoimmune Hemolytic Anemia is caused by

A

IgG and Igm specific for surface antigens of RBC’s

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21
Q

Bence-Jones Proteins

A

Cryoglobulins composed only of light chains

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22
Q

Cause of Grave’s Disease

A

IgG binds to TSH receptor –> Overproduction of thyroid hormone

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23
Q

Cellular mediator of Multiple Sclerosis

A

Th1 CD4 Effector Cells –> Activate macrophages

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24
Q

Cryoglobulins

A

Ig’s that become insoluble at reduced temperature

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25
Cyroglobulins are most often produced by patients that have
B cell proliferative disorder (multiple myeloma, etc)
26
Damage from Goodpasture's Syndrome
Kidney damage
27
Dx of Autoimmiune Thrombocytopenic Purpura
Microangioplastic Hemolytic Anemia
28
Goodpasture's Syndrome
IgG specific for Type-IV collagen (basement membranes)
29
Guillan Barre Syndrome
Type 2 AI disease mediated by IgG specific for gangliosides --> Demyelination
30
IgG binds to TSH receptor --> Overproduction of thyroid hormone
Cause of Grave's Disease
31
IgG specific for ACh receptors on muscle cells
Myasthenia Gravis
32
IgG specific for Desmoglein 1 and 3 --> Loss of cohesion in keratinocytes in epidermis
Pemphigus Vulgaris
33
IgG specific for Type-IV collagen (basement membranes)
Goodpasture's Syndrome
34
IgG-mediated inhibition of an enzyme responsible for cleavage of vWF
Autoimmune (Idiopathic) Thrombocytopenic Purpura
35
Immune-Complex Diseases
(1) Subacute Bacterial Endocarditis; (2) Mixed Essential Cryoglobulinemia; (3) Systemic Lupus Erythematosus
36
Inflammatory destruction of vascular endothelial cells of arterioles and SM cells; replacement with collagen and fibrous material
Scleroderma
37
Meltzer's Triad
Purpura, Athralgia, Myalgia; Mixed Essential Cryoglobulinemia
38
Mixed Essential Cryoglobulinemia is a common sequelae to
Infection with Hepatitis C
39
Myasthenia Gravis
IgG specific for ACh receptors on muscle cells
40
Organ effected by Addison's Disease
Adrenal Gland
41
Pemphigus Vulgaris
IgG specific for Desmoglein 1 and 3 --> Loss of cohesion in keratinocytes in epidermis
42
Rhematoid Factor
IgG, IgM, and IgA specific for the Fc region of antibody molecules
43
Scleroderma
Inflammatory destruction of vascular endothelial cells of arterioles and SM cells; replacement with collagen and fibrous material
44
Symptoms of Mixed Essential Cryoglobulinemia
Meltzer's Triad: Purpura, Athralgia, Myalgia
45
Symptoms of Pemphigus Vulgaris
Painful chronic blisterin of skin
46
Treatment of Autoimmune Hemolytic Anemia
Corticosteroids
47
Type 2 AI disease mediated by anti-neutrophil cytoplasmic Ab's (ANCAs)
Wegener's Granulomatosis
48
Type 2 AI disease mediated by IgG specific for gangliosides --> Demyelination
Guillan Barre Syndrome
49
Type 3 Autoimmune Conditions are mediated by
IgG, immune complex disease
50
Type sof Ab's in Scleroderma
Anti-nuclear, Anti-topo, Anti-centromere
51
Wegener's Granulomatosis
Type 2 AI disease mediated by anti-neutrophil cytoplasmic Ab's (ANCAs)
52
What initiates Subacute Bacterial Endocarditis
IgG that binds microorganisms that have colonized damaged heart valves
53
What mediates inflammation in Subacute Bacterial Endocarditis
Phagocytes that recognize opsonized bacteria; Anaphylotoxins
54
Which is immediate type hypersensitivity
Type 1
55
Allergens for immediate-type HS are often
proteases (think parasites)
56
Cellular mediator of Tuberculin reaction
Th1 CD4 T cells
57
Effect of IL-4 and IL-13 from Mast Cells
Stimulate and amplify TH2-cell response
58
Effect of Leukotrienes from Mast Cells
SM contraction, Vascular permeability, Mucus secretion
59
Effect of Mast Cells on Airways
Decreased diameter, increased mucus secretion
60
Effect of Mast Cells on GI tract
Increased fluid secretion and peristalsis
61
Farmer's Lung
Inhaling mold spores and other allergens from hay --> Chronic deposition of immune complexes
62
Immune reactant for Type 2 HS?
IgG
63
Immune reactant for Type 3 HS?
IgG
64
Major cytokine of Mast Cells
TNF-alpha
65
Mast Cell enzymes
Tryptase, Chymase, Cathepsin G, Carboxypeptidase
66
Mast Cell toxic mediators
Histamine, Heparin
67
Most Common Type 3 Hypersensitivities
Farmer's Lung, Bird-Fancier Disease
68
Time frame of Type 2 HS?
4-12 hours
69
Time frame of Type 4 HS?
24-72 hours
70
Type 1 HS allergens must be __ bc they only induce ___ responses
proteins, T cell
71
What initiates type 1 HS?
Mast cell degranulation (IgE crosslinking)
72
What initiates type 2 HS?
Allergen-specific IgG Ab's (mediated by complement, phagocytes, and NK cells)
73
What mediates type 2 HS after initiated?
Complement cascade, phagocytes, and NK cells
74
What mediates Type 4 HS?
T cells (either 4 or 8)
75
Which is delayed-type hypersensitivity
Type 4
76
Which is immune complex type hypersensitivity
Type 3
77
Which is modified self type hypersensitivity
Type 2

Immunology 2 (9 decks)

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