Transplant Flashcards
(16 cards)
Principle tissues affected in GvH Disease
Skin, Intestines, Liver (inflammation of bile duct)
3 most often used immunosuppressives for transplant
Corticosteroids, Cytotoxic, Microbial Products
3 Symptoms of GvH Disease:
(1) Maculopapular Skin Rash; (2) High Serum Levels of Bilirubin; (3) Diarrhea
Major cause of morbidity and mortality after bone marrow transplantation
Graft vs Host disease
Most common cause of hyperacute rejection
Mismatched blood types
Most important action of corticosteroids
Inhibit NFKB
Most important action of Cytotoxic drugs in immunosuppression
Kill proliferating lymphocytes by interfering with DNA replicaiton
Most important action of microbial products in transplant
Inhibit signaling pathways for T cell activation
Only genetic factor that must be considered before liver transplantation
ABO Blood groups
T/F: The placenta expresses MHC
False, fetal tissue
The alloreactions that occur following blood transfusion to not involve
T cells
Timeline of Acute Rejection
11-15 days after transplantation (absence of anti-inflammatory)
Timeline of rejection mediated solely by minor histocompatibility antigens
30-60 days
Timeline of Second-Set Acute Rejection
4-7 days
What mediates Acute Rejection
CTL’s
Why is the cornea immunologically privileged
Not vascularized
