Tumor Flashcards
(23 cards)
Tumor-associated antigen
Unmutated protein that is encoded in germline of a cell whose expression level has been dramatically altered by neoplastic process
A developing thymocyte that undergoes a neoplastic event will express
CD1
A T cell that undergoes a neoplastic event after reaching thymic medulla will express
CD3 and either CD4 or CD8
Ab drugs against CTLA-4 do what
Antagonists, prevent CTLA-4 from binding B7 –> Prevents Tregs from performing effector function –> More T cell activation
Action of Blinatumomab
Recruits CD8T cells to tumor, resulting in T cell killing of tumor cells
Action of CTLA-4
Binds to B7 molecules, preventing CD28 from doing so; Treg secretes TGF-beta
Action of CTLA-4 on Tregs
Serves as activator of Treg effector function –> Produce TGF-Beta
Antigen targeted by Bevacizumab
VEGF
Antigen targeted by Trastuzumab
Her2/Neu
B/t 1/3 and 1/2 of human tumors have defects in expression of
One or more HLA Class I Haplotypes
Binds to B7 molecules, preventing CD28 from doing so
Action of CTLA-4
Cancers caused by EBV
Burkitt’s Lymphoma, Nasopharyngeal Carcinoma
Clinical utility of MUC-1
Tumor-specific carb and peptide epitopes; Candidate for use in a tumor vaccine (breast carcinoma)
Function of PD-L1
Some tumors express; Ligand for PD-1 on effector T cells; Negative regulator of T cell function
Lymphomas may be dx as B-cell-derived tumors by expression of
CD20
PD-1 ligands are normally expressed on
APCs in secondary lymphoid tissues
Recruits CD8T cells to tumor, resulting in T cell killing of tumor cells
Action of Blinatumomab
T/F: NK cells are not involved in immunity to tumors
FALSE
Tumor cells that express PD-L1 are protected from
CTL-mediated killing
Unmutated protein that is encoded in germline of a cell whose expression level has been dramatically altered by neoplastic process
Tumor-associated antigen
When bound, PD-1 is a
negative regulator of T cell effector function
Where is CTLA-4 located
Surface of Naïve T cells and T regs
Where is PD-1 expressed?
Effector T cells
