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Autoimmunity Flashcards

(57 cards)

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1
Q

what is he immune system

A

system has self tolerant mechanisms - when breakdown autoimmunity occur

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2
Q

what develops in autoimmunity

A

autorecative T cells and Ab which recognise self antigens

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3
Q

what is an organ specific autoimmunity

A

hasjmoto’s thyroiditis

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4
Q

what kind of autoimmunity involves many organs

A

systemic lupus erythematosus

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5
Q

what is SLE

A

non organ sp

one of dominant Ab directed ag cell nucleus

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6
Q

what happens in hashimotts disease

A

enlarged thyroid

Ab directed against thyroglobulin

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7
Q

what is the normal pathology of thyroid gland

A

acing epithelial cells secerete thyroglobulin into colloid spaces

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8
Q

what happens to pathology of thyroid gland in hashimotos disease

A

normal architecture virtually destroyed, replaced by invading cells - lymphocytes, macrophages and plasma cells

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9
Q

in autoimmunity Ab bind to

A

self antigens

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10
Q

what are Ab said to be

A

in serum

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11
Q

what are some autoimmune thyroid diseases

A

hashimoto’s thyrodiditis

primary myoexedema thyrotoxicosis

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12
Q

what is an autoimmune disease of stomach

A

pernicious anaemia

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13
Q

what is an autoimmune disease of adrenal gland

A

addison disease

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14
Q

what is the autoimmune disease of pancreas

A

insulin dept diabetes mellitus

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15
Q

what re some non organ sp autoimmune diseases

A

muscle - dermatomyositis
kidney - SLE
skin - scleroderma
Joints - rheumatoid arthritis

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16
Q

can an individual have more than one autoimmune disease at a time

A

yes

rheumatoid arthritis often ass with SLE

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17
Q

are autoimmune diseases hereditary

A

can occur in families

certain HLA haplotypes predispose to autoimmunity

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18
Q

what are the HLA haplotypes for hashimotos

A

HLA - DR5

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19
Q

what re the HLA haplotypes for RA

A

HLA-DR1

HLA-DR4

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20
Q

what are the HLA assc fro addisons

A

HLA- B8

HLA- DR3

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21
Q

what r the assc HLA asc with IDDM

A

HLA- DR3
HLA- DR4
HLA- DR3/4

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22
Q

what are the HA assc with myasthenia gravis

A

HLA - DR3

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23
Q

what are the HLA assc fro multiple sclerosis

Study These Flashcards
A

HLA - DR2

HLA - DQ6

24
Q

what are the HLA assc with SLE

25
what is the prevalence of autoimmune diseases
3.5% population have
26
who are more likely to autoimmune diseases men or woman
woman 2.7 X more likely to do with sex hormones?
27
what can be seen as a typical sign of SLE in the face
'malar' flush
28
what is thyrotoxicosis ( graves disease)
human Ab directly pathogenic | act on receptor stimulating thyroid cell and over prod of thyroid hormones
29
what causes pernicsiou anaemia
auto ab against intrinsic factor
30
what does intrinsic factor normally do
abs Vitamin B12
31
what is immunopathological damage (A)
when auoAb local to organ type 2 hyper and cell mediated reactions damage due to complement and phagocyte degranulation
32
what is immunopathological damage (B)
immune complexes = pathogenic in system SLE deposits of IC type 3 hyper reactions acute tissue damage
33
what si the pathology of rheumatoid arthritis
inflammatory infiltrate found in synovial mem erosion coat and bone IC and neutrophils present in joint space Ic = self assc of rheumatoid factors
34
what are some examples affecting head and neck
``` hashimoto thyroiditis hashimoto's persistent goiter autoimmune colloid goiter graves disease non-goitrous hyperthyroidism HT + Graves simultaneously Primary Myxedema ```
35
what does hoshimotos thyroiditis do
thyroid destruct
36
what does hashimotos persistent goiter do
destroy thyroid | stimulate cell div
37
what does autoimmune colloid goiter do
tim cell div
38
what does graves disease do
stim cell div | stim thyroid hormone release
39
what does non goitrous hyperthyroidism do
stim thyroid hormone syn
40
what does HT + graves simultaneously do
destroy thyroid | stim thyroid hormone syn
41
what does primary myxedema do
destroy thyroid inhibit cell div inhibit TH syn
42
what is cicatricial pemphigoid
chronic autoimmune disease of mucosal mess and/or skin | lining of mouth common site
43
what is sjogrens disease
chronic inflam auto disease | alone or asc with SLE, RA
44
what are the majority of sjjogrens disease pt's
woman | 4th-5th decade show symptoms start in 1st-2nd decade
45
how common is sjorgens disease
1-2% population
46
what is sjogrens disease characterised by
lymphocytic infiltrate in salivary and lacrimal glands | slow destroy and replace glandular tissue with fibrotic
47
what happens to saliva in sjogrens syndrome
lack of saliva and tear secretion dental caries oral candida
48
what is seen from sjogrens disease
dry lips dry lobulated tongue caries
49
what are ways of treat autoimmune disorders
metabolic control anti inflam drugs immunosuppressive drugs monoclonal Ab
50
what is an example of metabolic control of autoimmune disorder
anti thyroid drugs in graves disease | inject vitB12 in perniciuous anaemia
51
what re see antiimflam drugs used ag autoimmune
corticosteroids or NSAIDs
52
what is an immunosuppressive drugs
cyclosporin
53
what do monoclonal Ab do
blockade certain cytokines or their receptors e.g. infliximab block TNF
54
what is monoclonal Ab
prep where all mols identical
55
what is rheumatoid arthritis treated with
anti-TNF(alpha) Ab and methotrexate
56
what does depletion of b cels do
by monoclonal Ab alleviates symptoms of SLE
57
what si the marker for b cells
CD20

Immunology (10 decks)

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