Hypersensitivity Flashcards
(40 cards)
what is hypersensitivity
exaggerated innaprotpriate adaptive immune response
what can be a result of hypersensitivity
inflammation and tissue damage
what can hylprsenstiiy be provoked by
many antigens
who will a hyper reaction occur
no manifest on 1st contact with Ag usually appears on the rcontact
what are the classes of hyper
1, 2, 3, 4
how are types 1 2 3 mediated
antibody
how is type 4 mediated
by T cells and macrophages
what is type 1 hyper
IgE response to innocuous enviro antigens
what are some examples of innocuous enviro antigens
pollen
dust mites
animal hair
latex
what doe IgE bind to
F(epsilon)RI on mast cells bind very tight as high affinity
what does the second encounter with allergen do
triggers release inflam mediators
what does type 1 produce
acute inflam reactions within minutes with symptoms such as asthma
what are some major allergens for type 1 hyper
house mites a
pollen - ragweed
what happens when allergic response release of
histamine
prostangladins
other mediators
leukotrienes
what are som treatments for type 1 hyper
avoidance
sodium chromoglycate
anti histamines
desnsitiitaiton
what is anaphltactic shock
severe type 1 reactions with systemic symptoms life threat
what are some symptoms of anaphylactic shock
wheeze swelling of face laryngopharynx nausea dizziness
how is anaphylactic shock treated
adrenaline immediately
what is imp for dentist to know anaphylactic shock
type 1 reactions to anaesthetics can occur can create generalised anaphylaxis so always have adrenaline near
what is type 3 hyper
antibody dept cytotoxic hyper
when does type 3 occur
12-18 hours after Ab expo
what causes type 3
IgM or IgM binds to either self antigen or foriegn causing phagocytosis kileer cell active
what is a primary example of type 3
blood transfusion reaction when ABO incompatible blood is transferred
what are some symptoms of blood tran incompatible
fever hypotension nausea vomiting pain in back or chest
