Autonomic drugs Flashcards Preview

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Flashcards in Autonomic drugs Deck (25):
1

Alpha-1 receptors

1) Gq
2) Vascular contraction, mydriasis, intestinal and bladder sphincter contraction

2

Alpha-2 receptors

1) Gi
2) Decreased insulin secretion, decreased lipolysis and increased platelet aggregation

3

Beta-1

1) Gs
2) Increased HR, contractility, increased renin, increased lipolysis

4

Beta-2

1) Gs
2) Increased HR, contractility, increased lipolysis, increased insulin release, decreased uterine tone, ciliary muscle relaxation, increased aqueous humor

5

Bethanechol

1) Cholinomimetic, resistance to AChE
2) Postoperative ileus, neurogenic ileus and urinary retention

6

Carbachol

1) Cholinomimetic
2) Glaucoma

7

Pilocarpine

1) Cholinomimetic
2) Sweat, tears, saliva
3) Glaucoma

8

Edrophonium

1) Increases endogenous ACh
2) Diagnosis MG

9

Donepezil

1) Increases endogenous ACh
2) Alzheimer's

10

Scopolamine

1) Anti-muscarinic
2) Motion sickness

11

Oxybutynin

1) Anti-muscarinic
2) Reduces bladder spasm

12

Glycopyrrolate

1) Anti-muscarinic
2) Post operatively used to reduce secretions
3) Drooling, peptic ulcer

13

Isoproterenol

1) Beta-selective sympathomimetic
2) Torsades, bradyarrhythmias (can worsen ischemia)

14

Dobutamine

1) Beta-1 selective sympathomimetic
2) Heart failure, stress test

15

Phenylephrine

1) Alpha selective sympathomimetic
2) Decongestant

16

Terbutaline

1) Beta-2 selective sympathomimetic
2) Reduces uterine contractions (premature labor)

17

Ritodine

1) Beta-2 selective
2) Reduces premature uterine contractions

18

Clonidine; alpha-methyldopa

1) Centrally acting alpha-2 agonists
2) Hypertension with renal disease

19

Phentolamine

1) Reversible alpha-blocker
2) MAOI + tyramine crisis

20

Mirtazapine

1) Alpha-2 blocker
2) Depression -> increases sleeping and appetite

21

Timolol

Beta-blockers which can be used for glaucoma

22

Metoprolol; esmolol

Beta-blockers which can be used for SVT's

23

B1-selective antagonists

*for pulmonary disease (A BEAM)
Acebutolol
Betaxolol
Esmolol
Atenolol
Metroprolol

24

Non-selective beta-blockers

*Please Try Not Being Picky
Propanolol
Timolol
Nadolol
Pindolol

25

Non-selective alpha/beta antagonists (vasodilatory)

1) Carvedilol
2) Labetalol