Autonomic drugs Flashcards
(25 cards)
Alpha-1 receptors
1) Gq
2) Vascular contraction, mydriasis, intestinal and bladder sphincter contraction
Alpha-2 receptors
1) Gi
2) Decreased insulin secretion, decreased lipolysis and increased platelet aggregation
Beta-1
1) Gs
2) Increased HR, contractility, increased renin, increased lipolysis
Beta-2
1) Gs
2) Increased HR, contractility, increased lipolysis, increased insulin release, decreased uterine tone, ciliary muscle relaxation, increased aqueous humor
Bethanechol
1) Cholinomimetic, resistance to AChE
2) Postoperative ileus, neurogenic ileus and urinary retention
Carbachol
1) Cholinomimetic
2) Glaucoma
Pilocarpine
1) Cholinomimetic
2) Sweat, tears, saliva
3) Glaucoma
Edrophonium
1) Increases endogenous ACh
2) Diagnosis MG
Donepezil
1) Increases endogenous ACh
2) Alzheimer’s
Scopolamine
1) Anti-muscarinic
2) Motion sickness
Oxybutynin
1) Anti-muscarinic
2) Reduces bladder spasm
Glycopyrrolate
1) Anti-muscarinic
2) Post operatively used to reduce secretions
3) Drooling, peptic ulcer
Isoproterenol
1) Beta-selective sympathomimetic
2) Torsades, bradyarrhythmias (can worsen ischemia)
Dobutamine
1) Beta-1 selective sympathomimetic
2) Heart failure, stress test
Phenylephrine
1) Alpha selective sympathomimetic
2) Decongestant
Terbutaline
1) Beta-2 selective sympathomimetic
2) Reduces uterine contractions (premature labor)
Ritodine
1) Beta-2 selective
2) Reduces premature uterine contractions
Clonidine; alpha-methyldopa
1) Centrally acting alpha-2 agonists
2) Hypertension with renal disease
Phentolamine
1) Reversible alpha-blocker
2) MAOI + tyramine crisis
Mirtazapine
1) Alpha-2 blocker
2) Depression -> increases sleeping and appetite
Timolol
Beta-blockers which can be used for glaucoma
Metoprolol; esmolol
Beta-blockers which can be used for SVT’s
B1-selective antagonists
*for pulmonary disease (A BEAM) Acebutolol Betaxolol Esmolol Atenolol Metroprolol
Non-selective beta-blockers
*Please Try Not Being Picky Propanolol Timolol Nadolol Pindolol
