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Final Step 1 Review > Pulmonary > Flashcards

Flashcards in Pulmonary Deck (12):
1

H1-blockers (first generation)

1) Diphenhydramine, dimenhydrinate, chlorpheniramine
2) Used for allergy, motion sickness, sleep aid
3) Causes sedation, anti-muscarinic effects, anti-alpha effects

2

H1-blockers (second generation)

1) Loratadine, fexofenadine, desloratadine, cetirizine
2) Used for allergy
3) Far less sedating than first generation because of decreased CNS entry

3

Long acting beta-2 agonists

1) Salmeterol, formoterol
2) Asthma prophylaxis
3) Cases tremors and arrhythmias

4

Theophylline

1) PDE-I -> increases cAMP
2) Cardiotoxic and neurotoxic
3) Metabolized by p450
4) Blocks action of adenosine

5

Ipratropium

1) Competitive block of muscarinic receptors -> prevents bronchoconstriction
2) Tiotropium can be used for COPD; ipratropium used for asthma

6

Beclomethasone; fluticasone

1) Corticosteroids that are used first line for chronic asthma
2) Inactivate NF-kB which blocks TNF-alpha production

7

Montelukast; zafirlukast

1) Block leukotriene receptors
2) Good for aspirin-induced asthma

8

Zileuton

Asthma medication which inhibits 5-lipooxygenase -> blocks conversation of arachidonic acid to leukotrienes

9

Omalizumab

Monoclonal anti-IgE antibody which is used in allergic asthma resistant to inhaled steroids and long-acting beta-2 agonists.

10

Guaifenesin

Expectorant which thins respiratory secretions and does not suppress cough reflex

11

Dextromethorphan

1) Antitussive which antagonizes NMDA glutamate receptors
2) Synthetic codeine analog which can have opioid effects -> abuse/ overdose potential

12

Pseudoephedrine; phenylephedrine

1) Sympathomimetic alpha-agonist
2) Reduces edema and nasal congestion; can open obstructed eustation tubes
3) Causes HTN and anxiety