autonomic nervous system Flashcards
(66 cards)
autonomic is a division of what part of the nervous system
peripheral nervous system
parts of the ANS
sympathetic and parasympathetic and enteric nervous system
neurons that arise from CNS
preganglionic fibers
where do pre ganglionic fibers synapse
ganglia
neurons that arise from ganglia and synapse of effector tissue
post ganglionic fibers
preganglionic sympathetic and parasympathetic fibers release what
Acetylcholine
parasympathetic post ganglionic fibers release what
acetylcholine
sympathetic post ganglionic fibers release what
norepinephrine (mostly) and epinephrine
Acetylcholine synthesis
acetyl CoA + choline via choline acetyltransferase
nicotinic receptors are what type of receptor
ligand gated ion channels: ionotropic
muscarinic receptors are what type of receptor
g-protein coupled- metabotropic
what is M2 receptor and where is it
a muscarinic receptor in the heart and glands
what is M3 receptor and where is it
muscarinic receptor in smooth muscle
structure of metabotropic receptors
7 TM receptor with alpha, beta and gamma subunits
M1, M3, M5 receptors bound to what G protein and what does it do
Gq activate PLC to increase intracellular Calcium stores
M2, M4 bound to what G protein and what does it do
Gi which inhibits adenylyl cyclase and lowers cAMP
what does M3 do
causes calcium release form internal stored via IP3 receptor
what does MLCK do
initiates cross bridge cycling after calcium influx
is an action potential necessary to contract smooth muscle
no, it can be contacted via a graded potential
what activated MLCK?
influx of calcium
smooth muscle cell relaxation mechanism
cAMP
dopamine is involved in what
motivation, reward, motor control
what NTs mediate post ganglionic sympathetic transmission
norepinephrine, epinephrine
what type of receptors are dopaminergic and adrenergic receptors
metabotropic
