Autonomic Pharmacology Resp- Trachte Flashcards Preview

CRRAB II- FINAL > Autonomic Pharmacology Resp- Trachte > Flashcards

Flashcards in Autonomic Pharmacology Resp- Trachte Deck (29):
1

What is released from preganglionic sympathetic nerves? What receptor does it bind to?

ACh on nicotinic receptors

2

what does activation of alpha 1 receptor do?

Contraction of vascular smooth muscle

Epi=NE >>> isoproterenol

DOES NOT AFFECT BRONCHIOLES

3

What can an alpha 1 agonist due in response to cold?

Constriction of smooth vasculature can be used for decongestion

4

What does activation of B2 receptor do?

Relaxes bronchial smooth muscle

Iso > Epi >>>> NE

Epi is the natural stimulus for B2 receptor activation

5

What is released from preganglionic parasympathetic nerves? what receptor does it bind to?

ACh on nicotinic receptors

6

What is released from postganglionic parasympathetic nerves? what receptor does it bind to?

ACh on muscarinic receptors

7

What effect does activating a muscarinic receptor have?

Bronchial constriction
Increased secretions

8

How would a muscarinic antagonist affect secretion production?

A muscarinic antagonist would decreased production of secretions

9

What is the most effective therpay for acute bronchospasm?

B2 agonist

Metaproterenol
Terbutaline
Albuterol

10

Metaproterenol

B2 agonist

11

Terbutaline

B2 agonist

12

Albuterol

B2 agonist

13

Slameterol

long acting B2 agonist

14

What are the major sideeffects of B2 agonists?

Tachycarida and palpitations (B1 stimulation)

Tremor (skeletal muscle B2 stimulation)

Headache (vasodilation in CNS)

15

How often should a patient with well controlled asthma be using a short-acting B2 agonist?

only twice per week (not counting uses for exercise)

16

Epinerphrine

Acts to relax broncioles by binding B2

ONLY USE FOR ANAPHYLAXIS

17

Isoproterenol

Synthetic catecholamine stimulating B receptors

Relaxes bronchioles (B2)

18

Ephedrine

Reverses axoplasmic NE pump - releases NE

Cardio- increases BP
Resp- relaxes bronchioles

Constricts vasculature- used as decongestant

19

Pseudoephedrine

Stereoisomer of ephedrine commonly used to treat nasal congestion

Constricts vasculature

20

Phenylephrine

direct alpha 1 agonist

Constricts vasculature- used as decongestent

21

Ipratropium

Muscarinic antagonist

Bronchodilator for chornic obstructive pulmonary disease

22

Tiotropium

Long acting muscarinic antagonist

Bronchodilator for COPD

23

What are the recommended treatments for COPD?

1. Short acting B2 agonist
2. Long acting B2 agonist
3. Long acting muscarinic antagonist
4. Glucocorticoids (fluticasone, budesonide)

24

Pulmonary Side effect of propranolol?

B-blockers

Increase airway resistance, particularly in asthmatics (B2 antagonism)

25

Bethanecol MOA, and what is the pulmonary side effect?

Muscarinic agonist- can cause bronchoconstriction

26

Neostigmine MOA, and what is the pulmonary side effect?

Anticholinesterase- potentiates acetylocholine actions on muscarinic receptors to cause bronchoconstriction

27

Terazosin MOA, and what is the pulmonary side effect?

alpha 1 antagonist- can causes mucosal congestion

28

Guanethidine MOA, and what is the pulmonary side effect?

NE-depleting agents- can causes mucosal stuffiness

29

Lisinopril MOA, and what is the pulmonary side effect?

ACE inhibitor- can cause cough and angioedema