Flashcards in Genetics- Bemis Deck (13):
What homozygous mutation would lead to immunity from HIV?
Homozygous mutation in CCR5
What would a heterozygous CCR5 mutation should in a person infected with HIV?
Slower course of disease
Why is resistance common to HIV drugs?
RT is not a very reliable transcriptase- many mistakes!!! Causes a high number of mutations in viral genome
What drug would no longer be effective if the HIV virus had tropism for only CXCR4?
Maraviroc - CCR5 antagonist
Individuals with the same genotype will show variation in phenotype
Genetics in Type I Diabetes
They encode the MHC II molecules
Genetic association vs. GWAS
Genetic association: one gene or a few genes
GWAS: massive data
how can you determine Relative risk for an anorexia nervosa in first degree relatives?
What asses frequency of disease and related risk factors at a particular point in time?
What kind of study was done in the AN paper Bemis wanted us to read?
Is AN monogenic or polygenic?
Results in increased expression of another gene