Genetics- Bemis Flashcards Preview

CRRAB II- FINAL > Genetics- Bemis > Flashcards

Flashcards in Genetics- Bemis Deck (13):
1

What homozygous mutation would lead to immunity from HIV?

Homozygous mutation in CCR5

2

What would a heterozygous CCR5 mutation should in a person infected with HIV?

Slower course of disease

3

Why is resistance common to HIV drugs?

RT is not a very reliable transcriptase- many mistakes!!! Causes a high number of mutations in viral genome

4

What drug would no longer be effective if the HIV virus had tropism for only CXCR4?

Maraviroc - CCR5 antagonist

5

Variable expressivity

Individuals with the same genotype will show variation in phenotype

6

Genetics in Type I Diabetes

HLADR3
HLADR4
They encode the MHC II molecules

7

Genetic association vs. GWAS

Genetic association: one gene or a few genes

GWAS: massive data

8

how can you determine Relative risk for an anorexia nervosa in first degree relatives?

Cohort study

9

What asses frequency of disease and related risk factors at a particular point in time?

Cross-sectional study

10

What kind of study was done in the AN paper Bemis wanted us to read?

GWAS

11

Is AN monogenic or polygenic?

Polygenic

12

Modifier Gene

Results in increased expression of another gene

13

Allelic heterogeneity

Different mutations in the same locus produce the same phenotype