Pharmacology 2- Regal/Trachte Flashcards Preview

CRRAB II- FINAL > Pharmacology 2- Regal/Trachte > Flashcards

Flashcards in Pharmacology 2- Regal/Trachte Deck (24):
1

Diphenhydramine

-First gen. antihistamine
Blocks H1, muscarinic, alpha adrenergic, and serotonin receptors
-Low incidence of GI side effects
-Sedation!!!

2

Chlorpheniramine

-First gen. antihistamine
Blocks H1, muscarinic, alpha adrenergic, and serotonin receptors

-Most suitable for day time use

3

What are the 2 first generation anti-histamines we need to know?

Diphenhydramine
Chlorpheniramine

4

Cetirizine

Second gen. antihistamine → blocks H1
Minimal anticholinergic properties
Do not cause sedation and drying of secretions (less penetration into CNS)
Not cardiotoxic

5

Fexofenadine

Second gen. antihistamine → blocks H1
Minimal anticholinergic properties
Do not cause sedation and drying of secretions (less penetration into CNS)
Not cardiotoxic

6

Loratadine

Second gen. antihistamine → blocks H1
Minimal anticholinergic properties
Do not cause sedation and drying of secretions (less penetration into CNS)
Not cardiotoxic

7

What are the 3 second generation anti-histamine drugs?

Cetirizine
Fexofenadine
Loratadine

8

Why is it that second generation anti-histamines are non-sedating?

They have an affinity for P-glycoprotein efflux pump in brain, and get pumped out of the CNS

9

Why is it that second generation anti-histamines do not cause drying secretions?

They have minimal anticholinergic properties

10

Theophylline

MOA is controversial
Adenosine antagonist
Inhibits phosphodiesterase (inhibits cAMP to AMP) causing bronchodilation

Narrow TI! Cardiotoxic and Neurotoxic

Caffeine part of this class

11

Albuterol

Short acting B2 agonist
Relaxes bronchial smooth muscle during acute asthma exacerbation

12

Salmeterol

Long-acting B2 agonist for prophylaxis.

Adverse effects are tremor and arrhythmia

13

Zileuton

5-lipoxygenase inhibitor
Stops conversion of AA to leukotrienes

14

Zafirlukast

blocks leukotriene receptor CysLT1, especially good for aspirin-induced asthma

15

Montelukast

blocks leukotriene receptor CysLT1, especially good for aspirin-induced asthma

16

Phenylephrine

Alpha-1 agonist

17

Pseudoephedrine

Acts on alpha and Beta receptors

-vasoconstriction and increase in nasal airway dilation

18

Prednisone

Induces lipocortin to inhibit PLA2 and inhibit cytokine synthesis

19

Triamcinolone

Corticosteroid-reduces inflammatory cells in nasal mucosa

20

Flunisolide

Glucocorticoid receptor agonist

21

Omalizumab

Binds to circulating IgE and blocks if from binding to IgE receptor on surface of mast cells and basophils

22

What mediators are the cause of asthma?

Leukotrienes

23

Fondaparinux

Binds Antithrombin III, increasing its ability to inhibit Factor Xa

24

Argatroban, Bivalirudin

Inhibit Thrombin directly