Autonomic Rx Flashcards
(55 cards)
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Bethanchol</p>
<p>1) Activates Bowel and Bladder smooth m. Post-op and neurogenic ileus and urinary retention.
2) Direct Cholinomimetic.
4) Resistant to AchE.</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Carbachol</p>
<p>1) Glaucoma, pupillary contraction, and relief of intraocular pressure.
2) Direct Cholinomimetic.
4) Carbon copy of Ach</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p class=”large” style=”text-align:center”;>Pilocarpine</p>
<p class=”large” style=”text-align:center”;>1) Potent stim of sweat, tears, saliva. Contracts ciliary m of eye (open angle) and pupillary sphincter (narrow angle)
2) Direct Cholinomimetic
4) Resistant to AchE</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Methacholine </p>
<p>1) Challenge test --> dx of asthma.
2) Direct Cholinomimetic, stim muscarinic r in airway</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Neostigmine</p>
<p>1) Post-op and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular jxn blockade (post-op).
2) Indirect Cholinomimetic; increases Ach.
4) No CNS penetration</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Pyridostigmine</p>
<p>1) Myasthenia gravis (long acting)
2) Indirect Cholinomimetic; increases Ach, increases strength.
4) No CNS penetration</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Edrophonium </p>
<p>1) Diagnosis of myasthenia gravis (short acting).
2) Indirect Cholinomimetic; increases endogenous Ach</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Physostigmine</p>
<p>1) Anticholinergic toxicity
2) Indirect Cholinomimetic; increases Ach.
4) crosses BBB</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Donepezil</p>
<p>1) Alzheimers
| 2) Indirect Cholinomimetic; increases Ach</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>ADE of all Cholinomimetics</p>
<p>Exacerbation of COPD, asthma, and peptic ulcers</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p class=”large” style=”text-align:center”;>Organophosphate poisoning (e.g. Parathion)</p>
<p class=”large” style=”text-align:center”;>Irreversibly inhib AchE. (DUMBBELSS) Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal m and CNS, Lacrimation, Sweating, and Salivation</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Rx for Organophosphate poisoning</p>
<p>Atropine + Pralidoxime = regenerate active AchE</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Atropine Use/MOA</p>
<p>1) Blocks Organophosphate poisoning. Used to treat bradycardia and opthalmic applications
2) Muscarinic antagonist. </p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Atropine ADE</p>
<p>3) Increase body temp, rapid pulse, dry mouth, dry/flushed skin, cycloplegia, constipation. Can cause acute angle-glaucoma in elderly, urinary retention in men with BPH, hyperthermia in infants</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Homatropine</p>
<p>1) Produce mydriasis and cycloplegia
2) Muscarinic antagonist</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Tropicamide</p>
<p>1) Produce mydriasis and cycloplegia
2) Muscarinic antagonist</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Benztropine</p>
<p>1) Rx for Parkinsons.
2) Muscarinic Antagonist</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Scopolamine</p>
<p>1) Motion sickness.
2) Muscarinic antagonist</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p class=”large” style=”text-align:center”;>Tiotropium</p>
<p class=”large” style=”text-align:center”;>1) Rx for COPD, Asthma.
2) Muscarinic antagonist</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Ipratropium</p>
<p>1) Rx for COPD, Asthma.
2) Muscarinic antagonist</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Oxybutynin</p>
<p>1) Reduce urgency in mild cystitis and reduce bladder spasms.
2) Muscarinic Antagonist</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Glycopyrrolate</p>
<p>1) Parenteral: preop --> reduce airway secretions. PO: Rx for drooling, peptic ulcer
2) Muscarinic Antagonist</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>Epinephrine</p>
<p>1) Anaphylaxis, glaucoma (open angle), asthma, hypotension
2) Sympathomimetics; A1, A2, B1, B2. LOW dose selective for B1</p>
1) uses 2) class/ MOA 3) ADE 4)Fun fact/note
<p>NE</p>
<p>1) Hypotension (but low renal perfusion)
2) Sympathomimetics; A1, A2 > B1</p>
Isoproterenol
1) Torsade de pointes (tachycardia decr low QT interval), bradyarrhythmias (but can worsen ischemia) 2) Sympathomimetics; B1=B2
Dopamine
1) Shock (renal perfusion), heart failure 2) Sympathomimetic; D1 (low dose) >B (medium dose) >A (high dose), inotropic and chronotropic
Dobutamine
1) Heart failure, cardiac stress testing 2) Sympathomimetic; B1>B2, inotropic and chronotropic)
Phenylephrine
1) Hypotension (vasoconstrictor), ocular procedures (mydriatic), rhinitis (decongestant) 2) Sympathomimetic; A1>A2
Albuterol
1) Acute asthma | 2) Sympathomimetic; Selective B2-agonist (B2>B1)
Salmeterol
1) Long-term treatment of asthma or COPD control 2) Sympathomimetic; Selective B2-agonist (B2>B1)
Terbutaline
1) Reduce premature uterine contractions 2) Sympathomimetic; Selective B2-agonist (B2>B1)
Ritodrine
1) Reduces premature uterine contractions 2) Sympathomimetic; B2
Amphetamine
1) Narcolepsy, obesity, ADD 2) Indirect Sympathomimetic/general agonist, releases stored catecholamines
Ephedrine
1) Nasal decongestion, urinary incontinence, hypotension 2) Indirect sympathomimetic/general agonist, releases stored catecholamines
Cocaine
1) Causes vasoconstriction and local anesthesia 2) Indirect sympathomimetic/general agonist. Uptake inhibitor. 4) People use this to get high. Don't give B-blockers if cocaine intoxication suspected.
Clonidine
1) HTN esp w renal disease (no decr in blood flow to kidney) 2) Sympathoplegics. Centrally acting A2-agonist. Decr central sympathetic outflow
Alpha-methyldopa
1) HTN esp w renal disease (no decr in blood flow to kidney) 2) Sympathoplegics. Centrally acting A2-agonist. Decr central sympathetic outflow
Phenoxybenzamine
1) Pheochromocytoma (b4 removing tumor) 2) Irreversible, Nonselective alpha blocker 3) Orthostatic hypotension, reflex tachycardia
Phentolamine
1) Give to pts on MAO-i who eat tyramine-containing foods 2) Reversible, Nonselective alpha blocker
Prazosin
1) HTN, urinary retention in BPH 2) A1 blocker 3) 1st dose orthostatic hypotension, dizziness, HA
Terazosin
1) HTN, urinary retention in BPH 2) A1 blocker 3) 1st dose orthostatic hypotension, dizziness, HA
Doxazoin
1) HTN, urinary retention in BPH 2) A1 blocker 3) 1st dose orthostatic hypotension, dizziness, HA
Tamsuolosin
1) HTN, urinary retention in BPH 2) A1 blocker 3) 1st dose orthostatic hypotension, dizziness, HA
Mirtazapine
1) Depression 2) A2 blocker 3) Sedation, incr serum cholesterol, incr appetite
Acebutolol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Beta1-antagonist (partial Beta-agonist) 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics
Betaxolol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Beta1-antagonist 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics
Esmolol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Beta1-antagonist (short acting) 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics
Atenolol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Beta1-antagonist 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics
Metoprolol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Beta1-antagonist 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics
Propanolol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Non-selective B-antagonist 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure sleep alteration). Use with caution in diabetics
Timolol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Non-selective B-antagonist 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics
Pindolol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Non-selective B-antagonist (partial B-agonist) 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics
Labetalol
1) HTN, Angina pectoris,MI, SVT, CHF, Glaucoma 2) Non-selective A and B antagonist 3) Impotence, exacerbations of asthma, cardio (bradycardia, AV blok, CHF), CNS (sedation, seizure, sleep alteration). Use with caution in diabetics
Carvedilol
Non-selective A and B antagonist
Nadolol
Non-selective B antagonist
